Abstract
The prognostic variables in patients with metastatic cutaneous nodal squamous cell carcinoma (SCC) are well documented; however, the relationship between lymph node ratio (LNR) and outcome is not well researched. LNR represents the ratio of positive lymph nodes to total excised lymph nodes. We analyzed the correlation between LNR and outcome in patients who have undergone surgery for metastatic cutaneous nodal SCC of the head and neck. Analysis was performed on retrospectively collected data, identifying patients who underwent surgery at Westmead Hospital, Sydney. Pathology reports were reviewed to ascertain LNR. A log-rank test identified a specific LNR value to compare time to disease progression (TTDP) and overall survival (OS). Multivariate proportional hazard regression models were used to review outcome. In total, 193 males and 45 females with a median of age 68 years were identified, with a mean recorded LNR of 0.15. On multivariate analysis, an LNR cutpoint of 0.21 was a significant predictor of decreased TTDP [hazard ratio (HR) 2.34, 95 % confidence interval (CI) 4.40-0.49; p = 0.009] and OS (HR 2.75, 95 % CI 1.57-4.82; p < 0.001). Forty-nine of 238 patients (21 %) developed recurrence, with most recurrences being regi...Continue Reading
References
Jun 1, 1994·Journal of the National Cancer Institute·D G AltmanM Schumacher
May 4, 2005·The Laryngoscope·Michael J VenessVal Gebski
Sep 15, 2005·Head & Neck·Jacques BernierJ L Lefèbvre
Jan 31, 2006·Cancer·Jennifer L AndruchowChristopher J O'Brien
May 2, 2006·Cancer·Michael J VenessGary J Morgan
Dec 4, 2008·Annals of Surgical Oncology·Da-zhi XuQuentin Liu
Feb 19, 2009·Cancer·Nicolas OddoneMichael J Veness
Jan 7, 2010·Cancer·Veronique-Isabelle ForestChris Milross
Nov 24, 2011·Head & Neck·Jeffrey T WangMichael J Veness
Jan 19, 2012·The British Journal of Dermatology·A LomasF Bath-Hextall
May 15, 2012·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Aviram MizrachiGideon Bachar
Jul 19, 2012·Annals of Surgical Oncology·Jonathan R ClarkMichael J Veness
Oct 11, 2012·The Journal of Laryngology and Otology·J T WangM J Veness
Nov 21, 2012·The Medical Journal of Australia·Marloes FransenRodney D Sinclair
Feb 5, 2013·Journal of the American Academy of Dermatology·Pritesh S KariaChrysalyne D Schmults
Mar 5, 2013·World Journal of Surgery·Nüvit DurakerDavut Demir
Jun 20, 2013·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Julian KünzelHeinrich Iro
Oct 12, 2013·Cancer·Moran AmitUNKNOWN International Consortium for Outcome Research (ICOR) in Head and Neck Cancer
Dec 7, 2013·The Laryngoscope·Markus BrunnerJonathan R Clark
Mar 7, 2014·Head & Neck·Roshan S PrabhuJonathan J Beitler
Apr 15, 2014·Annals of Surgical Oncology·Ardalan EbrahimiZiv Gil
Citations
Jan 24, 2018·Head & Neck·Kartik VasanJonathan R Clark
Oct 24, 2018·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Alhasan N ElghoucheCecelia E Schmalbach
Mar 8, 2019·JAMA Otolaryngology-- Head & Neck Surgery·Axel SahovalerS Danielle MacNeil
Apr 12, 2019·ANZ Journal of Surgery·Ashish SoodArdalan Ebrahimi
Feb 18, 2020·The Laryngoscope·Samuel J TrosmanZoukaa B Sargi
Sep 20, 2019·OTO Open : the Official Open Access Journal of the American Academy of Otolaryngology--Head and Neck Surgery Foundation·Xinrui ZhangXuekui Liu
Oct 15, 2020·Future Oncology·Sam KeepingChrysalyne D Schmults
Jul 5, 2021·Oral Oncology·Mark D WilkieTerence M Jones