PMID: 11927011Apr 3, 2002Paper

Prognostic significance of matrix metalloproteinase-7 (MMP-7) expression at the invasive front in gastric carcinoma

Japanese Journal of Cancer Research : Gann
Xiu Ping LiuKohsuke Sasaki

Abstract

To evaluate the clinicopathological significance of matrix metalloproteinase-7 (MMP-7) expression in gastric carcinoma, we investigated immunohistochemically MMP-7 expression in 214 gastric carcinomas, and examined its relations with the clinicopathologic parameters including patient prognosis. MMP-7 expressed predominantly in cancer cells, and MMP-7-positive tumor cells were preferentially found in deeply invading nests, especially at the invasive front. The mean MMP-7 labeling index (LI) at the invasive front was significantly higher in tumors invading or penetrating the muscularis propria and in stages II - IV than within the submucosal layer and in stage I, respectively (P < 0.001). Statistical analysis revealed that MMP-7 LI at the invasive front was related to lymph node metastasis, vascular invasion, and lymphatic permeation, when all 214 cases were examined as one group (P < 0.05 for all), and the cases with high MMP-7 expression at the invasive front showed significantly more unfavorable prognosis as compared with that of low MMP-7 expression tumors (P < 0.01). Multivariate analysis revealed that TNM stage and MMP-7 expression status at the invasive front were independent prognostic factors (P = 0.0017, relative risk (...Continue Reading

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Citations

Jan 18, 2006·Digestive Diseases and Sciences·Masakazu YashiroKosei Hirakawa
Jul 7, 2011·World Journal of Gastrointestinal Oncology·Alexandra Mj LangersCornelis Fm Sier
Sep 21, 2013·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Kazuhiro SentaniWataru Yasui
May 20, 2008·Surgical Oncology Clinics of North America·Donato NittiMario Lise
May 3, 2005·Gastroentérologie Clinique Et Biologique·Franck ZinzindohouéPierre Laurent-Puig
Feb 5, 2005·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·H DoucasD P Berry
Mar 21, 2006·Biochimica Et Biophysica Acta·Yvan de LaunoitKathye Verreman
Jun 23, 2011·Clinica Chimica Acta; International Journal of Clinical Chemistry·Marta Lukaszewicz-ZającMaciej Szmitkowski
Mar 16, 2006·British Journal of Cancer·F J G M KubbenH W Verspaget
Oct 22, 2008·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Hui-Ching ChuangJiin-Haur Chuang
Jun 29, 2006·International Journal of Cancer. Journal International Du Cancer·Sari M SillanpääVeli-Matti Kosma
Jun 5, 2003·Expert Opinion on Therapeutic Targets·Barbara Fingleton
Jul 28, 2019·Journal of Clinical Medicine·Tatiana S GerashchenkoVladimir M Perelmuter

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