Prognostic significance of matrix metalloproteinase-9 (MMP-9) in stage II colorectal carcinoma.

Journal of Gastrointestinal Cancer
Abdelbaset BuhmeidaSeppo Pyrhönen

Abstract

Approximately 30% of all colorectal cancer patients are diagnosed with stage II disease. Adjuvant therapy is not widely recommended. However, it is well-established that a subgroup of patients with stage II is at high risk for recurrence within their life time and should be considered for adjuvant chemotherapy. The present work was designed to assess the value of matrix metalloproteinase-9 (MMP-9) as a predictor of disease outcome in a series of 202 stage II colorectal cancer (CRC) patients with long-term follow-up. The present study comprises a series of 202 patients who underwent bowel resection for stage II CRC at Turku University Hospital. Archival paraffin-embedded CRC tissue samples were used to prepare tissue microarray blocks for immunohistochemical staining with MMP-9 antibody. Forty-eight percent of all CRC samples were positive for MMP-9. There was no significant correlation between MMP-9 expression and age, depth of invasion, and lymph node status. However, MMP-9 expression was significantly related to histological grade (p = 0.03) and location of the tumor (p = 0.01), therefore, being lower in high-grade tumors and most intense in carcinomas of the descending colon and rectum. Tumors with high MMP-9 expression show...Continue Reading

References

Dec 1, 1996·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Z S ZengJ G Guillem
Aug 26, 1998·Biochemical and Biophysical Research Communications·J NiuM Agrez
Jan 23, 1999·The New England Journal of Medicine·C S FuchsW C Willett
Jul 31, 1999·The Journal of Cell Biology·C LegrandJ M Tournier
Jul 11, 2003·Annals of Oncology : Official Journal of the European Society for Medical Oncology·F Graziano, S Cascinu
Jun 12, 2004·Clinical Oncology : a Journal of the Royal College of Radiologists·M E MeliskoA Venook
Jun 17, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Al B BensonDaniel G Haller
Dec 30, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Stephanie CurranGraeme I Murray
Jan 10, 2006·Diseases of the Colon and Rectum·Marja HilskaPeter J Roberts
Jul 26, 2006·World Journal of Gastroenterology : WJG·Adam ElzagheidSeppo Pyrhonen
Mar 31, 2007·International Journal of Colorectal Disease·Piotr DanielEwa Malecka-Panas
Apr 10, 2007·International Journal of Cancer. Journal International Du Cancer·D Lee GordenLynn M Matrisian
Apr 25, 2007·International Journal of Cancer. Journal International Du Cancer·Marja HilskaMatti Laato
Nov 10, 2007·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·A SutnarL Holubec
Mar 19, 2008·Pathology Oncology Research : POR·László HerszényiZsolt Tulassay

❮ Previous
Next ❯

Citations

Nov 28, 2012·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Adam ElzagheidSeppo Pyrhönen
Dec 28, 2012·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Chun-Yu LiYan Wang
Jan 26, 2011·Journal of Gastroenterology and Hepatology·Kyung Sook ParkJin Cheon Kim
Aug 4, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Leanne StevensonPatrick G Johnston
Dec 12, 2012·BMC Clinical Pathology·Selja KoskensaloCaj Haglund
Dec 4, 2012·International Journal of Molecular Sciences·László HerszényiZsolt Tulassay
Mar 1, 2012·World Journal of Gastroenterology : WJG·Ana AbajoJesus Garcia-Foncillas
Nov 22, 2011·Molecular Aspects of Medicine·Diego SbardellaMassimo Coletta
Aug 31, 2010·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Søren Astrup JensenJens Benn Sørensen
Nov 1, 2016·Antioxidants & Redox Signaling·Graciele Almeida de OliveiraDavid A Wink
Oct 14, 2014·World Journal of Gastroenterology : WJG·László HerszényiZsolt Tulassay
Jul 26, 2013·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Deqiang DingYu-Sheng Cong
Jan 13, 2016·Journal of Experimental & Clinical Cancer Research : CR·Chenbo DingJihong Feng
Aug 20, 2020·Acta Cirúrgica Brasileira·Sandra Regina MoriniSarhan Sydney Saad
Dec 14, 2012·Applied Immunohistochemistry & Molecular Morphology : AIMM·Abd Al-Rahman Mohammad Foda

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.