PMID: 11725209Nov 29, 2001

Prognostic significance of melanoma inhibiting activity levels in malignant melanoma

Melanoma Research
R MeralN Dalay

Abstract

This analytic (phase II) study aimed to investigate the hypothesis that the decline in serum melanoma-inhibiting activity (MIA) levels following initiation of treatment might have prognostic value. The mean serum lactate dehydrogenase (LDH), MIA and S100 levels in patients with malignant melanoma before treatment were higher than in the control group. Patients with visceral dissemination had much higher mean serum MIA levels than patients with nodal spread only. A regression model was constructed to analyse the prognostic factors in patients with advanced stage malignant melanoma. Therapy included surgical excision or lymph node dissection, hypofractionated radiotherapy, and immunotherapy or chemotherapy. Blood samples were collected within 24 h before the initiation of systemic treatment and two or three times more at 20-28 day intervals. Overall survival was investigated by univariate analysis, and correlation with clinical factors was compared using the log-rank test. Gender, primary tumour site, surgery, radiation therapy, serum S100 levels before systemic treatment and choice of chemotherapy were not correlated with the outcome. In addition to the stage of disease, low serum LDH levels before systemic treatment and a decli...Continue Reading

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Oct 20, 2009·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Liqing ZhuangPeter Hersey
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Related Concepts

MIA protein, human
S100A1 protein
Lactate Dehydrogenase
Lymphatic Metastasis
Melanoma
Neoplasm Proteins
S100 Proteins
Malignant Neoplasm of Skin
Extracellular Matrix Proteins

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