PMID: 11725209Nov 29, 2001

Prognostic significance of melanoma inhibiting activity levels in malignant melanoma

Melanoma Research
R MeralN Dalay


This analytic (phase II) study aimed to investigate the hypothesis that the decline in serum melanoma-inhibiting activity (MIA) levels following initiation of treatment might have prognostic value. The mean serum lactate dehydrogenase (LDH), MIA and S100 levels in patients with malignant melanoma before treatment were higher than in the control group. Patients with visceral dissemination had much higher mean serum MIA levels than patients with nodal spread only. A regression model was constructed to analyse the prognostic factors in patients with advanced stage malignant melanoma. Therapy included surgical excision or lymph node dissection, hypofractionated radiotherapy, and immunotherapy or chemotherapy. Blood samples were collected within 24 h before the initiation of systemic treatment and two or three times more at 20-28 day intervals. Overall survival was investigated by univariate analysis, and correlation with clinical factors was compared using the log-rank test. Gender, primary tumour site, surgery, radiation therapy, serum S100 levels before systemic treatment and choice of chemotherapy were not correlated with the outcome. In addition to the stage of disease, low serum LDH levels before systemic treatment and a decli...Continue Reading


Aug 1, 1989·European Journal of Cancer & Clinical Oncology·K HeimdalS Gundersen
Jan 1, 1995·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M J StevensA Horwich
Aug 30, 1995·International Journal of Radiation Oncology, Biology, Physics·G K ZagarsA C von Eschenbach
Dec 1, 1993·The Journal of Investigative Dermatology·P BrossartW Hunstein
Jan 5, 1996·The Journal of Biological Chemistry·A BosserhoffR Buettner
Feb 9, 1996·The Journal of Biological Chemistry·U H Dietz, L J Sandell
Mar 1, 1996·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·J ViacA Claudy
Apr 1, 1997·Developmental Dynamics : an Official Publication of the American Association of Anatomists·A BosserhoffL J Sandell
Dec 19, 1998·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·A BosserhoffR Hein
Nov 24, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M DeichmannH Näher
Oct 29, 2000·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·A JuergensenA Bosserhoff
Nov 25, 2000·Recent Results in Cancer Research. Fortschritte Der Krebsforschung. Progrès Dans Les Recherches Sur Le Cancer·A BosserhoffR Buettner


Oct 20, 2009·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Liqing ZhuangPeter Hersey
Dec 3, 2002·Melanoma Research·B GuidiP L Amerio
Jul 31, 2007·Cancer Investigation·Mark B FariesDonald L Morton
Oct 4, 2011·Mayo Clinic Proceedings·Shanique R PalmerSvetomir N Markovic
Jul 25, 2009·The British Journal of Dermatology·L Jennings, G M Murphy
Aug 30, 2008·International Journal of Cancer. Journal International Du Cancer·Simone MocellinDonato Nitti
Apr 29, 2005·Journal of the American Academy of Dermatology·J Andrew CarlsonMartin C Mihm
Jul 22, 2014·Journal of Skin Cancer·Angela SandruAlexandru Blidaru
Dec 18, 2007·Seminars in Oncology·Hussein A Tawbi, John M Kirkwood
Feb 1, 2007·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·G S MissottenJ M Bonfrer
Jun 24, 2003·Rapid Communications in Mass Spectrometry : RCM·E RagazziP Traldi
Feb 23, 2005·Expert Review of Molecular Diagnostics·Gerald P LinetteJeffrey S Ross
Sep 1, 2016·Melanoma Management·Ricardo Moreno-TraspasSusana Ortiz-Urda

Related Concepts

MIA protein, human
S100A1 protein
Lactate Dehydrogenase
Lymphatic Metastasis
Neoplasm Proteins
S100 Proteins
Malignant Neoplasm of Skin
Extracellular Matrix Proteins

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