Prognostic significance of multidrug resistance gene 1 (MDR1), multidrug resistance-related protein (MRP) and lung resistance protein (LRP) mRNA expression in acute leukemia.

Journal of Korean Medical Science
Hee Jin HuhThad Ghim

Abstract

The prognostic significance of multidrug resistance (MDR) gene expression is controversial. We investigated whether multidrug resistance gene 1 (MDR1), multidrug resistance-related protein (MRP) and lung resistance protein (LRP) mRNA expression are associated with outcomes in acute leukemia patients. At diagnosis we examined MDR1, MRP and LRP mRNA expression in bone marrow samples from 71 acute leukemia patients (39 myeloid, 32 lymphoblastic) using nested RT-PCR. The expression of each of these genes was then expressed as a ratio in relation to beta-actin gene expression, and the three genes were categorized as being either 0, 1+, 2+ or 3+. MDR1, MRP and LRP mRNA expression was detected in 23.9%, 83.1% and 45.1 %, respectively. LRP mRNA expression was significantly associated with resistance to induction chemotherapy in acute leukemia patients, and in the AML proportion (p=0.02 and p=0.03, respectively). MRP and high MDR1 mRNA expression was associated with poorer 2-yr survival (p=0.049 and p=0.04, respectively). Patients expressing both MRP and LRP mRNA had poorer outcomes and had worse 2-yr survival. The present data suggest that MDR expression affects complete remission and survival rates in acute leukemia patients. Thus, de...Continue Reading

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Citations

Sep 4, 2012·Indian Journal of Hematology & Blood Transfusion : an Official Journal of Indian Society of Hematology and Blood Transfusion·Ghada M ElsayedManar M Moneer
May 28, 2010·Pharmacogenomics·Ekaitz Errasti-Murugarren, Marçal Pastor-Anglada
Mar 22, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Fang WangLi-Wu Fu
Jul 29, 2011·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Bin ZhangHong-zhang Huang
Jan 8, 2013·Journal of Clinical Laboratory Analysis·Ana Carolina Rabello de MoraesMaria Cláudia Santos-Silva
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Jun 29, 2013·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Chrysoula DoxaniElias Zintzaras
Dec 9, 2009·Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners·Jehan A El-SharnoubyRasha Elashry
Apr 5, 2018·Leukemia & Lymphoma·Gabriela Antonio-AndrésSara Huerta-Yepez
Oct 22, 2011·The Korean Journal of Internal Medicine·Dong-Yeop ShinByoung-Kook Kim
Jul 16, 2019·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Yulin WangThomas Efferth
Mar 6, 2021·Critical Reviews in Oncology/hematology·Flavia Cunha VasconcelosRaquel Ciuvalschi Maia

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Methods Mentioned

BETA
density
bone marrow aspiration
PCR

Software Mentioned

SPSS
ImageMaster

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