Prognostic significance of neutrophil-lymphocyte ratio and carbohydrate antigen 19-9 in patients with gallbladder carcinoma

Medicine
Fei LiuFu-Yu Li

Abstract

The neutrophil-lymphocyte ratio (NLR) is an immune response-related indicator and it is associated with poor prognosis of various cancers. The carbohydrate antigen19-9 (CA19-9) is a tumor-associated antigen and it has prognostic relevance in gallbladder carcinoma (GBC). We aimed to analyze whether preoperative NLR and serum CA19-9 were associated with outcomes of GBC patients after surgery with curative intent.Between January 2010 and May 2015, 90 resectable GBC patients who underwent curative surgery in our institution were included. All final diagnoses were confirmed by pathologic examination. The demographics, clinical, and histopathology data were analyzed. The Cox regression proportional hazard model and Kaplan-Meier method were used to assess prognostic factors.The cutoff values of 4.33 and 250.90 U/mL were defined as high NLR and high CA19-9, respectively. The univariate analyses showed that TNM stage, lymph node metastasis, the degree of tumor differentiation, margin status, combined hepatectomy, CA19-9, NLR, and PNI were all associated with overall survival (P < .05). According to the multivariable analysis, NLR (hazard ratio (HR) 3.840, 95% confidence interval (95% CI): 2.122-6.947, P < .001), CA19-9 (HR 2.230, 95% CI...Continue Reading

References

Nov 1, 1979·Somatic Cell Genetics·H KoprowskiP Fuhrer
Dec 13, 2002·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·H PuhallaT Gruenberger
Mar 24, 2004·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Hiromichi ItoEdward E Whang
Aug 17, 2004·Immunity·Gavin P DunnRobert D Schreiber
Feb 3, 2005·Journal of Gastroenterology and Hepatology·Yogesh BatraRakesh Kumar Tandon
Dec 27, 2008·Journal of Hepato-biliary-pancreatic Surgery·Shuichi MiyakawaTakukazu Nagakawa
Mar 24, 2011·Cancer Research·Alyssa D Gregory, A McGarry Houghton
Apr 26, 2011·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·J M RegimbeauO Farges
Sep 23, 2014·International Journal of Cancer. Journal International Du Cancer·Hongmei ZengXue Qin Yu
May 6, 2015·Indian Journal of Surgical Oncology·Veda Padma Priya SelvakumarKapil Kumar
Jun 17, 2015·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·Y ZhangX Qu
Jul 15, 2015·Korean Journal of Hepato-biliary-pancreatic Surgery·Eun Kyung HongYeon Ho Park
May 26, 2016·Asian Pacific Journal of Cancer Prevention : APJCP·Sushma AgrawalRajan Saxena
Jun 28, 2016·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Lingqiang ZhangChang Liu
Sep 30, 2016·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Eliza W BealCarl R Schmidt
Jan 21, 2017·Journal of Gastrointestinal Cancer·Sushma AgrawalRajan Saxena
Jun 28, 2017·World Journal of Gastroenterology : WJG·Aarti SharmaAshok Kumar

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Citations

Mar 22, 2020·Annals of Surgical Oncology·Amika MoroTimothy M Pawlik
Sep 2, 2020·BMC Cancer·Ashish SachanPramod K Mishra
Mar 10, 2021·Journal of Gastrointestinal Cancer·Gulcan Bulut, Zehra Narli Ozdemir
Nov 11, 2021·Journal of Gastrointestinal Cancer·Abhay K KattepurMahesh Goel

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