Prognostic significance of p16 protein levels in oropharyngeal squamous cell cancer

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Paul M WeinbergerAmanda Psyrri

Abstract

Functional inactivation of p16 is an early and frequent event in head and neck squamous cell cancers. In this study, we sought to determine whether p16 expression is of prognostic importance in oropharyngeal squamous cell carcinoma. p16 protein expression was evaluated by immunohistochemistry in a tissue microarray composed of 123 oropharyngeal squamous cell cancers with a mean patient follow-up time of 33 months. p16 overexpression was associated with more advanced Tumor-Node-Metastasis stage and higher histologic grade. Despite this association with unfavorable features, p16 overexpression was associated with decreased 5-year local recurrence rates (11 versus 53%) and increased 5-year disease-free survival (62 versus 19%) and overall survival (60 versus 21%). In multivariate analysis, p16 expression status remained an independent prognostic factor for local recurrence, disease-free survival, and overall survival. In patients with oropharyngeal squamous cell carcinoma, overexpression of p16 as determined by immunohistochemistry is associated with significantly improved prognosis and lower local recurrence rates.

References

Jul 16, 2003·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·S Nicholas AgoffLaura A Koutsky

❮ Previous
Next ❯

Citations

Apr 14, 2011·Pathology Oncology Research : POR·László TamásTibor Krenács
Aug 7, 2013·Clinical Oncology : a Journal of the Royal College of Radiologists·K K OguejioforC M L West
Sep 3, 2013·The Lancet Oncology·Ranee MehraErica A Golemis
Jun 28, 2011·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·James S LewisBruce H Haughey
May 17, 2011·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Danielle H CarpenterJames S Lewis
May 19, 2012·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·James S LewisSamir K El-Mofty
Apr 29, 2010·Annals of Oncology : Official Journal of the European Society for Medical Oncology·C A FischerL M Terracciano
Jul 1, 2010·The American Journal of Surgical Pathology·James S LewisSamir K El-Mofty
Sep 20, 2012·Cancer Research·Caihua LiangKarl T Kelsey
Apr 8, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Eirini PectasidesAmanda Psyrri
Feb 4, 2014·Current Oncology Reports·John P Finnigan, Andrew G Sikora
Jan 21, 2014·International Journal of Clinical Oncology·Tomoya Yokota
Apr 11, 2014·Annals of Oncology : Official Journal of the European Society for Medical Oncology·G MountziosA Psyrri
May 17, 2012·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Jens JakschaClaude A Fischer
Sep 21, 2011·Expert Review of Anticancer Therapy·Maria J Worsham
Oct 18, 2008·Expert Review of Anticancer Therapy·Susan Ann Burchill
Aug 6, 2013·Otolaryngologic Clinics of North America·Pablo H Montero-Miranda, Ian Ganly
Jun 10, 2015·Experimental and Molecular Pathology·Montserrat ReyesFrancisco Aguayo
Apr 27, 2010·Cancer Treatment Reviews·Marie-Catherine VozeninEric Deutsch
Nov 11, 2009·Annales de pathologie·Cécile BadoualHélène Roussel
May 12, 2009·International Journal of Radiation Oncology, Biology, Physics·Christina S KongQuynh-Thu Le
Nov 1, 2006·American Journal of Clinical Pathology·Anna Fen-Yau LiJeou-Yuan Chen
Sep 26, 2015·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Haïtham MirghaniPhilippe Vielh
Jan 30, 2007·Oral Oncology·P K TsantoulisV G Gorgoulis
Jan 20, 2007·International Journal of Cancer. Journal International Du Cancer·Niklas ReimersJens P Klussmann
Feb 7, 2008·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Raghu RadhakrishnanMark W Lingen
Jan 3, 2013·Head & Neck·Clint T AllenRavindra Uppaluri
Jun 22, 2010·The Laryngoscope·Paul M WeinbergerWilliam S Dynan
Jun 1, 2013·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Alexander GröbeMarco Blessmann
Aug 21, 2010·International Journal of Cancer. Journal International Du Cancer·Per AttnerEva Munck-Wikland
Mar 5, 2013·International Journal of Cancer. Journal International Du Cancer·Dana HolzingerFranz X Bosch

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.

Cancer Genomics (Keystone)

Cancer genomics approaches employ high-throughput technologies to identify the complete catalog of somatic alterations that characterize the genome, transcriptome and epigenome of cohorts of tumor samples. Discover the latest research using such technologies in this feed.

Related Papers

The New England Journal of Medicine
Gabriele Rossi
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Paul M WeinbergerAmanda Psyrri
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Pernille LassenJens Overgaard
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Danny RischinGrant A McArthur
© 2021 Meta ULC. All rights reserved