PMID: 15239028Jul 9, 2004Paper

Prognostic significance of p53 and FHIT in advanced oropharyngeal carcinoma

American Journal of Otolaryngology
Jose E Otero-GarciaHarold Kim

Abstract

To determine the prognostic significance of p53 and fragile histidine triad (FHIT) expression in advanced oropharyngeal squamous cell carcinoma. A retrospective collection of clinical data was correlated with the protein expression. The expression of p53 and FHIT in specimens from patients with previously untreated advanced squamous cell carcinoma of the oropharynx was determined by immunohistochemistry. The expression of p53 and FHIT was statistically correlated with survival outcome. The primary endpoints were overall survival and disease-free survival. Thirty-four patients were analyzed in this study. Overexpression of p53 was observed in 41.2% (14/34) of tumors and was associated with a trend toward an improved overall survival using univariate (P =.1088, risk ratio [RR] = 0.503) and multivariate (P =.1533, RR = 0.470) analyses. Marked reduction or complete absence of FHIT expression was observed in 57.6% (19/33) of tumors. Patients with tumors showing no reduction in FHIT expression had a lower overall survival using univariate (P =.04, RR = 2.27) and multivariate (P =.013, RR = 4.41) analyses. Overexpression of p53 predicted a trend toward an improved prognosis, whereas no reduction in FHIT expression predicted a signific...Continue Reading

References

Jan 1, 1995·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·M E Guay, P Lavertu
Nov 6, 1996·Journal of the National Cancer Institute·W M KochD Sidransky
Feb 12, 1998·Proceedings of the National Academy of Sciences of the United States of America·Z SiprashviliK Huebner
Mar 25, 1999·The Laryngoscope·J S ChomchaiG H Yoo
Oct 4, 2000·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·K NylanderP A Hall

❮ Previous
Next ❯

Citations

Feb 10, 2010·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Sankalap TandonTerence M Jones
Apr 20, 2010·Pathology, Research and Practice·Halil KiyiciBeyhan Demirhan
Jul 7, 2009·International Journal of Radiation Oncology, Biology, Physics·Carlo FallaiPatrizia Olmi
Nov 29, 2005·International Journal of Experimental Pathology·Giovana R ThomasJacinto Regalado
Nov 4, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Wei ShiFei-Fei Liu
Nov 9, 2010·Nutrition and Cancer·Weimin GuoMohsen Meydani
Feb 4, 2006·Archives of Pathology & Laboratory Medicine·Leana A GuerinRobert A Robinson

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.

© 2022 Meta ULC. All rights reserved