Prognostic significance of p53 nuclear and cytoplasmic overexpression in right and left colorectal adenocarcinomas

European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)
X F SunB Nordenskjöld

Abstract

The prognostic significance of nuclear and cytoplasmic p53 protein, detected immunocytochemically using CM1 and PAb 1801 antibodies, was evaluated in right-sided and left-sided colorectal adenocarcinomas from 293 patients. CM1 nuclear and cytoplasmic p53 accumulation occurred in 38 and 25% of cases, respectively. PAb 1801 nuclear staining occurred in 18%, with no cytoplasmic staining. CM1 expression either in the nucleus or in the cytoplasm was positively related to PAb 1801 expression (P < 0.001 and P = 0.009, respectively). The incidence of CM1 nuclear and cytoplasmic expression was more frequent in right-sided tumours (P = 0.023 and P = 0.034, respectively), while PAb 1801 nuclear staining was more common in left-sided tumours (P = 0.011). In survival analyses, CM1 nuclear overexpression in the right-sided tumours (P = 0.016) and CM1 cytoplasmic overexpression in left-sided tumours (P = 0.04) were prognostic indicators, independent of Dukes' stage, DNA ploidy, PAb 1801 expression and each other. Further analysis showed that the prognostic value of CM1 nuclear expression was greater in right-sided tumours than in left-sided tumours (P = 0.018). The nuclear and cytoplasmic p53 protein detected with CM1 and PAb 1801 may play di...Continue Reading

References

Nov 1, 1992·The Journal of Clinical Investigation·T Frebourg, S H Friend
Nov 1, 1991·The Journal of Pathology·R A WalkerJ M Varley
Jul 5, 1991·Science·M HollsteinC C Harris
Jul 17, 1991·Journal of the National Cancer Institute·J Cossman, R Schlegel
Jan 1, 1990·Genes & Development·D P Lane, S Benchimol
Jul 1, 1989·Baillière's Clinical Gastroenterology·P Hermanek
Jan 1, 1994·Virchows Archiv : an International Journal of Pathology·M ZhaoA Zimmermann
Jan 1, 1993·Virchows Archiv. A, Pathological Anatomy and Histopathology·X F SunB Nordenskjöld
May 7, 1993·Science·S N ThibodeauD Schaid

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Citations

Apr 6, 2001·Diseases of the Colon and Rectum·S PetersenM Baumann
Jan 10, 2006·Diseases of the Colon and Rectum·Marja HilskaPeter J Roberts
Aug 6, 1999·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·G AdellB Nordenskjöld
Dec 16, 1998·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·R A PopescuC F Rochlitz
Mar 10, 2000·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·O SchwandnerR Broll
Sep 6, 2003·Surgical Oncology·Morton S KahlenbergNicholas J Petrelli
Jun 18, 2002·Journal of Cellular Physiology·Viviana BazanAntonio Russo
Apr 2, 2016·Research in Veterinary Science·Simone PagliaroneChiara Palmieri
Jun 24, 2010·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Toshiaki WatanabeHirokazu Nagawa
Jan 24, 2006·Journal of Clinical Epidemiology·Laura BagliettoJohn L Hopper
Aug 15, 2006·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Annelies DebucquoyKarin Haustermans
Jun 15, 2010·Experimental Cell Research·Valeriya Solozobova, Christine Blattner
Sep 17, 2005·Pathology, Research and Practice·Deniz YamacFulya Koybasioglu
May 1, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Megan M GarrityUNKNOWN North Central Cancer Treatment Group
Sep 29, 2000·International Journal of Cancer. Journal International Du Cancer·U ManneW E Grizzle
Oct 10, 2001·The Journal of Pathology·E KapiteijnJ H van Krieken
Mar 6, 2003·Human Mutation·Barry Iacopetta
Sep 16, 2005·Drugs·Ashita M Waterston, Jim Cassidy
Jun 26, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Milo FrattiniMarco A Pierotti
Nov 27, 2004·Journal of Surgical Oncology·Pascal GervazPhilippe Morel

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