Prognostic significance of platelet-to-lymphocyte ratio in patients with ovarian cancer: A meta-analysis

European Journal of Clinical Investigation
Chuan TianYong Sun

Abstract

The platelet-to-lymphocyte ratio (PLR) has been found to predict clinical outcomes in borderline ovarian tumours and the other genital neoplasms. However, its prognostic value in patients with ovarian cancer remains controversial. The aim of this study was to assess its prognostic value in ovarian cancer. We searched MEDLINE, EMBASE and the Cochrane databases to identify studies evaluating the prognostic significance of pretreatment PLR in ovarian cancer. The end points were overall survival (OS) and progression-free survival (PFS). Pooled hazard ratios (HRs) with 95% confidence intervals (CIs) were calculated using fixed-effects/random-effects models. A total of 11 studies comprising 3574 patients with ovarian cancer were included. The random-effects meta-analysis demonstrated that patients with elevated PLR had shorter OS (HR: 1.48, 95% CI: 1.24-1.76, P < .001) and PFS (HR: 1.38, 95% CI: 1.17-1.63, P < .001). The negative prognostic impact of high PLR on OS and PFS remained substantial in Asian populations, patients with PLR ≥ 200 and studies with NOS score ≥ 7. Elevated pretreatment PLR could be an unfavourable prognostic factor for clinical outcomes in patients with ovarian cancer.

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Citations

Feb 11, 2019·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Lixiao Yang, Huixiao Chen
Sep 17, 2020·Obstetrics & Gynecology Science·Asami IkedaIkuo Konishi
Feb 3, 2021·Zeitschrift für Geburtshilfe und Neonatologie·Betül YakıştıranAykan Yücel
Dec 6, 2020·Journal of Clinical Medicine·Avital VorontsovaYuval Shaked
Sep 23, 2021·International Journal of Cancer. Journal International Du Cancer·Yiming MiaoJingkun Zhao

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