Prognostic Significance of Premature Atrial Complexes Burden in Prediction of Long-Term Outcome

Journal of the American Heart Association
Chin-Yu LinShih-Ann Chen

Abstract

The prognostic significance of premature atrial complex (PAC) burden is not fully elucidated. We aimed to investigate the relationship between the burden of PACs and long-term outcome. We investigated the clinical characteristics of 5371 consecutive patients without atrial fibrillation (AF) or a permanent pacemaker (PPM) at baseline who underwent 24-hour electrocardiography monitoring between January 1, 2002, and December 31, 2004. Clinical event data were retrieved from the Bureau of National Health Insurance of Taiwan. During a mean follow-up duration of 10±1 years, there were 1209 deaths, 1166 cardiovascular-related hospitalizations, 3104 hospitalizations for any reason, 418 cases of new-onset AF, and 132 PPM implantations. The optimal cut-off of PAC burden for predicting mortality was 76 beats per day, with a sensitivity of 63.1% and a specificity of 63.5%. In multivariate analysis, a PAC burden >76 beats per day was an independent predictor of mortality (hazard ratio: 1.384, 95% CI: 1.230 to 1.558), cardiovascular hospitalization (hazard ratio: 1.284, 95% CI: 1.137 to 1.451), new-onset AF (hazard ratio: 1.757, 95% CI: 1.427 to 2.163), and PPM implantation (hazard ratio: 2.821, 95% CI: 1.898 to 4.192). Patients with frequen...Continue Reading

References

Oct 6, 1975·The American Journal of Cardiology·R C DhingraK M Rosen
Mar 7, 1987·Lancet·K M FlegelG Rose
Aug 1, 1983·American Heart Journal·W B KannelP M McNamara
May 19, 2000·International Journal of Epidemiology·T H LuM C Chou
Dec 21, 2011·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Boon-Hor ChongChung-Wah Siu
Jan 13, 2012·The New England Journal of Medicine·Jeff S HealeyUNKNOWN ASSERT Investigators
Apr 24, 2012·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Youhua Zhang, Todor N Mazgalev
Jul 10, 2012·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Hung-Yu ChangShih-Ann Chen
Aug 1, 2012·Pacing and Clinical Electrophysiology : PACE·Christina F PacchiaMohamed H Hamdan
Aug 14, 2012·Journal of the American College of Cardiology·Kang-Ling WangChern-En Chiang
Jan 15, 2013·Journal of the American Heart Association·Uchenna OfomaDuanping Liao
Jul 23, 2013·International Journal of Cardiology·Tze-Fan ChaoShih-Ann Chen
Oct 22, 2013·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Cheng-Yang HsiehMing-Liang Lai
Dec 4, 2013·Annals of Internal Medicine·Thomas A DewlandGregory M Marcus

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Citations

Jul 22, 2016·International Journal of Cardiology·Marios KoliosJohn A Goudevenos
Jul 8, 2016·Nature Reviews. Cardiology·Brandon W CalendaChristopher B Granger
May 24, 2017·Expert Review of Cardiovascular Therapy·Michala Herskind SejrPeter Brønnum Nielsen
Jan 7, 2017·Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc·Michelle L MeyerLaura R Loehr
Jun 8, 2018·European Journal of Endocrinology·Jessica PepeSalvatore Minisola
Oct 12, 2019·Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc·Eser DurmazZeki Ongen
Feb 6, 2017·PloS One·Joylene E SilandMichiel Rienstra
Jul 8, 2017·Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing·Hugo-Enrique CoutiñoGian-Battista Chierchia
Oct 30, 2018·Journal of the American Heart Association·Andrew C NickelFaisal M Merchant
Dec 7, 2018·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Jelle C L HimmelreichHenk C P M van Weert
Mar 4, 2021·Indian Pacing and Electrophysiology Journal·Aniruddha SinghKristopher S Pfirman

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