Prognostic significance of preoperative prognostic nutritional index in hepatocellular carcinoma: a meta-analysis

HPB : the Official Journal of the International Hepato Pancreato Biliary Association
Zhongran ManHuichun Liu

Abstract

To date, epidemiological evidence of the association between preoperative prognostic nutritional index (PNI) and the prognosis of hepatocellular carcinoma (HCC) remains controversial. A literature search was performed in the databases of PubMed, Embase, and Web of Science. Hazard ratio (HR), odds ratio (OR), and 95% confidence interval (CI) were extracted to estimate the association of preoperative PNI with overall survival (OS), disease-free survival (DFS), and postoperative recurrence of HCC, respectively. A random-effects model was used to calculate the pooled effect size. Thirteen studies with a total of 3,738 patients with HCC met inclusion criteria for this meta-analysis. It indicated that a lower level of preoperative PNI was a significant predictor of worse OS (HR = 1.82, 95%CI: 1.44-2.31) and DFS (HR = 1.49, 95% CI: 1.06-2.07). In addition, risk of postoperative recurrence was significantly higher in patients with a lower preoperative PNI (OR = 1.92, 95% CI: 1.33-2.76). Subgroup analysis based on therapeutic intent demonstrated a significant positive association between preoperative low PNI and worse OS for those patients undergoing surgical resection and for those undergoing TACE or non-surgical treatment. The current...Continue Reading

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Citations

Dec 11, 2019·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Xiaoxiao FanHui Lin
Feb 6, 2021·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Shuanggang ChenWeijun Fan
Aug 21, 2021·Liver International : Official Journal of the International Association for the Study of the Liver·Jinshu ZengJinhua Zeng
Dec 1, 2021·Annals of Hepato-biliary-pancreatic Surgery·Ho JeongSanghyun Song

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