Sep 1, 1987

Prognostic significance of pretreatment variables in patients with invasive cervical cancer

European Journal of Cancer & Clinical Oncology
E R te VeldeR E Ballieux


In 119 consecutive patients with invasive cervical cancer 92 variables of potential significance in predicting recurrence were determined before treatment. In 49 patients recurrent disease was diagnosed during follow-up after therapy. The investigated variables include: clinical data, routinely performed hematological and biochemical tests, histopathological data, oncofetal antigens, placental and pregnancy associated substances, serum levels of acute phase reactants, complement components, immunoglobulins and circulating immune complexes, and assays measuring the general immune competence of the patient. Thirty-three of the variables appeared to give statistically significant differences between values of future recurrence and non-recurrence patients. Further selection was carried out by stepwise forward discriminant analysis. This selection resulted in a prognosis rule using a subset of 7 variables. Carcino-embryonic antigen and the complement component C3PA appeared to be the most powerful variables. Although the stage of disease was the third most important single variable, it did not add prognostic information, once CEA and C3PA were used. By applying the prognosis rule a probabilistic prediction is obtained for each patie...Continue Reading

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Mentioned in this Paper

Neoplasm Recurrence, Local
Complement Component 2 Deficiency
Recurrent Malignant Neoplasm
Carcinoembryonic Antigen
Embryonic antigen
Complement Factor Bb
Recurrence (Disease Attribute)
Immune complex

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