PMID: 9187696Jun 1, 1997Paper

Prognostic significance of prostate-specific antigen in stage T1c prostate cancer treated by radical prostatectomy

Urology
M S CooksonW R Fair

Abstract

Increasingly, nonpalpable prostate-specific antigen (PSA)-detected (Stage T1c) tumors are being treated with curative intent. Presently, only limited information is available regarding pathologic findings correlated with preoperative PSA levels. Herein, we report the characteristics of Stage T1c tumors in a contemporary surgical series. Clinical and pathologic results in 107 patients with Stage T1c tumors treated with radical prostatectomy were compared with those in 300 patients with palpable (Stage T2) tumors. Multivariate analysis was performed to determine which clinical variables independently predicted pathologic staging. Stage T1c tumors were equivalent to Stage T2 tumors with respect to organ-confined and margin-positive rates. PSA level was the strongest independent predictor of extracapsular and margin-positive rates (P = 0.003). The absence of palpability was not a significant predictor of pathologic outcome. Significantly higher rates of organ- and specimen-confined disease were seen in patients with PSA levels less than 10.0 ng/mL, particularly less than 7.0 ng/mL. Patients with serum PSA levels greater than 20 ng/mL were at high risk for positive margins (relative risk 5.42, P < 0.001). Stage T1c tumors represent ...Continue Reading

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Citations

Oct 1, 1996·Urology·W R Fair, M B Garnick
Jul 27, 1999·International Journal of Radiation Oncology, Biology, Physics·G S MerrickJ H Lief
Sep 14, 2001·International Journal of Urology : Official Journal of the Japanese Urological Association·H MukouyamaY Ogawa
Feb 11, 2003·The Journal of Urology·Makoto OhoriThomas M Wheeler
Oct 22, 1998·International Journal of Urology : Official Journal of the Japanese Urological Association·O OgawaT Kato
Oct 14, 2006·Current Opinion in Urology·N Oakley
Sep 13, 2005·BJU International·Sandra A ArmatysLiang Cheng
Jan 4, 2012·Histopathology·Liang ChengDaniel M Berney
Jul 30, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Herbert AugustinPeter G Hammerer
Jul 16, 2005·Scandinavian Journal of Urology and Nephrology. Supplementum·John R SrigleyRodolfo Montironi
Apr 28, 2001·Cancer Control : Journal of the Moffitt Cancer Center·M M Cookson
Apr 16, 1998·Pathology·K A SikarisM D Guerin

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