Prognostic significance of resting heart rate in atrial fibrillation patients with heart failure with reduced ejection fraction

Heart and Vessels
Sho SuzukiKoichiro Kuwahara

Abstract

The prognostic significance of resting heart rate (HR) in atrial fibrillation (AF) patients with heart failure with reduced ejection fraction (HFrEF) is unclear, and there are no recommendations about the optimal HR in patients with HF in the current guidelines. Thus, we aimed to identify the relationship between resting HR and mortality in AF patients with HFrEF. A prospective multicenter cohort study was conducted between July 2014 and December 2018. We enrolled consecutive 144 AF patients with HFrEF (mean age 75 years, 34% female). The primary endpoint was all-cause death. We compared the outcomes between the high HR group (HR > 81 beats per minute [bpm], interquartile range [IQR] of HR ≥ 67%, n = 50), and the low HR group (HR ≤ 81 bpm, IQR of HR < 67%, n = 94). During a median follow-up of 538 days, the primary endpoint occurred in 41 (28.5%) patients. In Kaplan-Meier analysis, high HR was associated with a progressively increased risk of mortality (log-rank test, p = 0.034). After multivariate Cox regression analysis, high HR predicted all-cause death after adjusting for age, sex, hemoglobin, estimated glomerular filtration rate, LVEF, use of angiotensin-converting enzyme inhibitors, angiotensin II receptor blockers, beta-...Continue Reading

References

Jun 1, 1987·American Heart Journal·W B KannelL A Cupples
Dec 23, 1971·The New England Journal of Medicine·P A McKeeW B Kannel
Feb 7, 2002·JAMA : the Journal of the American Medical Association·Anju NohriaLynne Warner Stevenson
Jun 19, 2002·Circulation·Debra K Moser, Douglas L Mann
Dec 6, 2002·The New England Journal of Medicine·D G WyseUNKNOWN Atrial Fibrillation Follow-up Investigation of Rhythm Management (AFFIRM) Investigators
Oct 22, 2003·The Journal of Pharmacology and Experimental Therapeutics·Patrice ColinAlain Berdeaux
Sep 16, 2006·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Isabelle C Van GelderUNKNOWN RACE and AFFIRM Investigators
Jun 21, 2008·The New England Journal of Medicine·Denis RoyUNKNOWN Atrial Fibrillation and Congestive Heart Failure Investigators
Sep 2, 2008·Lancet·Jan-Christian Reil, Michael Böhm
Sep 17, 2009·Circulation Journal : Official Journal of the Japanese Circulation Society·Sanae HamaguchiUNKNOWN Japanese Cardiac Registry of Heart Failure in Cardiology Investigators
Mar 17, 2010·The New England Journal of Medicine·Isabelle C Van GelderUNKNOWN RACE II Investigators
Jun 24, 2014·JACC. Heart Failure·Damien CullingtonAndrew L Clark
Aug 28, 2016·European Heart Journal·Paulus KirchhofUNKNOWN ESC Scientific Document Group
May 4, 2017·Journal of the American College of Cardiology·Dipak KotechaUNKNOWN Beta-Blockers in Heart Failure Collaborative Group

❮ Previous
Next ❯

Citations

Oct 1, 2021·Circulation Journal : Official Journal of the Japanese Circulation Society·Hiroyuki TsutsuiUNKNOWN Japanese Circulation Society and the Japanese Heart Failure Society Joint Working Group

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antiarrhythmic Agents: Mechanisms of Action

Understanding the mechanism of action of antiarrhythmic agents is essential in developing new medications as treatment of cardiac arrhythmias is currently limited by the reduced availability of safe and effective drugs. Discover the latest research on Antiarrhythmic Agents: Mechanism of Action here.

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.

Atrial Filbrillation

Atrial fibrillation refers to the abnormal heart rhythm characterized by rapid and irregular beating of the atria. Here is the latest research.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.