Prognostic significance of sarcopenia in patients undergoing esophagectomy for superficial esophageal squamous cell carcinoma

Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus
J OgumaK Yatabe

Abstract

Nononcological prognostic factors in superficial esophageal squamous cell carcinoma (SESCC) patients remain unclear. The aim of this study is to evaluate the relationship between sarcopenia and surgical outcome in patients with SESCC who had undergone definitive surgery. A total of 194 SESCC patients who had undergone thoracic esophagectomy with three-field lymphadenectomy without neoadjuvant therapy at Tokai University Hospital between January 2006 and December 2015 were analyzed retrospectively. Manual tracing using CT imaging was used to measure the cross-sectional areas of the skeletal muscle mass. The cutoff values for the skeletal muscle index used to define sarcopenia were based on the results of a previous study. Twenty-eight patients (14.4%) had sarcopenia, while the remaining 166 patients (85.6%) did not. A multivariate analysis suggested that sarcopenia was an independent risk factor for postoperative pulmonary complications (OR = 3.232, P = 0.026). The overall survival rate and the disease-free survival rate were both significantly worse in the sarcopenia group than in the nonsarcopenia group (P < 0.001). In a multivariate analysis, sarcopenia was an independent prognostic factor affecting overall survival (HR = 7.1...Continue Reading

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Citations

Feb 11, 2020·Annals of Surgical Oncology·Pei-Yu WangYin Li
Jan 8, 2020·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·Han-Yu Deng, Rui Jiang
Mar 21, 2020·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·Dimitrios PapaconstantinouEmmanouil Pikoulis
Apr 17, 2021·Annals of Gastroenterological Surgery·Junya OgumaHiroyasu Makuuchi
Jun 16, 2021·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Marius KemperGeraldine de Heer
Jan 26, 2022·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·Fei ChenBin Ma

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