PMID: 11932896Apr 5, 2002Paper

Prognostic significance of serum thymidine phosphorylase concentration in esophageal squamous cell carcinoma

Cancer
Hideaki ShimadaTakenori Ochiai

Abstract

Thymidine phosphorylase (dThdPase), which also is referred to as platelet-derived endothelial cell growth factor, is a potent inducer of angiogenesis in malignant tumors. Increased dThdPase expression and activity have been found to be associated with poor prognosis in various solid tumor tissues. Because very little was known about the significance of serum dThdPase concentration (S-dThdPase), the objective of this study was to analyze the clinicopathologic significance of S-dThdPase in the patients with esophageal squamous cell carcinoma. The S-dThdPase was measured by enzyme-linked immunosorbent assay in 77 healthy controls and 153 patients with primary esophageal squamous cell carcinoma. A total of 80 patients underwent surgery alone; 46 patients received chemoradiotherapy alone; 17 patients received chemoradiotherapy followed by surgery; and 10 patients did not receive any treatment. Thymidine phosphorylase expression in esophageal carcinoma tissues was examined by immunohistochemistry. The clinicopathologic value and prognostic value of S-dThdPase was determined in 80 patients treated by surgery alone. The S-dThdPase is significantly higher in patients with esophageal carcinoma than in healthy controls (30.8 +/- 31.8 ng/m...Continue Reading

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Citations

Apr 15, 2003·Journal of the American College of Surgeons·Hideaki ShimadaTakenori Ochiai
Feb 27, 2007·Vascular Health and Risk Management·Roberta W C Pang, Ronnie T P Poon
Mar 5, 2011·Saudi Journal of Gastroenterology : Official Journal of the Saudi Gastroenterology Association·Ali AminianAlireza Mirsharifi
Feb 8, 2003·Journal of Gastroenterology·Hideaki ShimadaTakenori Ochiai
Jan 12, 2005·Cancer Investigation·M PatelBach Ardalan
Jul 24, 2015·Journal of Gastrointestinal Cancer·G R VermaS K Sinha
Dec 4, 2003·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·T NoguchiH E Gabbert
May 13, 2009·Medicinal Research Reviews·Annelies BronckaersSandra Liekens
Jun 26, 2003·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·H ShimadaT Ochiai
Jun 20, 2008·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·D-C LinM-R Wang
Jun 19, 2007·Biochemical Pharmacology·Sandra LiekensJan Balzarini
Jul 21, 2004·Gynecologic Oncology·Elzbieta Miszczak-ZaborskaJacek Bartkowiak
Apr 28, 2004·Journal of the American College of Surgeons·Hideaki ShimadaTakenori Ochiai
Sep 18, 2007·Orvosi hetilap·Krisztina Hagymási, Zsolt Tulassay
Feb 21, 2009·Orvosi hetilap·Krisztina Hagymási, Zsolt Tulassay
Jun 19, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Lih-Chyang ChenYu-Sun Chang
Feb 26, 2004·Journal of the American Chemical Society·Matthew R Birck, Vern L Schramm

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