PMID: 9420727Sep 1, 1994Paper

Prognostic significance of silent ischemia

Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology
S B PancholyA S Iskandrian

Abstract

This study examined the prognostic predictors in 521 patients with angiographic evidence of coronary artery disease (CAD). All patients underwent exercise single-photon emission computed tomographic thallium imaging. The patients were divided into those with symptomatic ischemia defined as reversible thallium defects, S-T segment depression (or both) and angina during exercise (n = 210, group 1), and silent ischemia defined as thallium defects or ST segment depression (or both) but no angina during exercise (n = 311, group 2). During a mean follow-up of 24 +/- 21 months, there were 30 cardiac events (death or nonfatal myocardial infarction). The extent of CAD (2.0 +/- 0.8 diseased vessels in group 1 and 2.1 +/- 0.8 diseased vessels in group 2), the left ventricular ejection fraction, the extent of perfusion abnormality (21% +/- 11% in group 1 and 24% +/- 12% in group 2), and the peak heart rate and double product were similar in the two groups. Survival analysis showed no significant difference in the event-free survival in patients with symptomatic or silent ischemia. The 2-year event-free survival rate was 95% in group 1 and 94% in group 2 (difference not significant). The extent of perfusion abnormality and history of diabet...Continue Reading

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Citations

Jul 1, 1996·European Journal of Nuclear Medicine·G Hör
Feb 5, 2008·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Ajay YerramasuDhakshinamurthy Vijay Anand
Jul 10, 2003·Journal of the American College of Cardiology·Michael J ZellwegerMatthias E Pfisterer
Jun 29, 2010·Diabetes/metabolism Research and Reviews·E MoralidisD P Mikhailidis

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