Prognostic Significance of Spot Urine Na/K for Longitudinal Changes in Blood Pressure and Renal Function: The Nagahama Study

American Journal of Hypertension
Yasuharu TabaraNagahama study group

Abstract

Urinary sodium-to-potassium ratio (Na/K) represents a simple measure of sodium load and has been reported to be associated with blood pressure (BP) levels in a cross-sectional setting even with spot measurements. The aim of the present large-scale cohort study is to determine prognostic significance of spot urine Na/K for longitudinal changes in BP levels and renal function. The present study population consisted of 7,063 individuals from the general population. Clinical parameters were measured at baseline and at a follow-up interval of 5 years. Mean systolic BP was slightly increased during the follow-up period (overall, 124 ± 17 to 125 ± 18 mm Hg; nontreated participants, 119 ± 15 to 122 ± 17 mm Hg). Although, the urinary Na/K demonstrated a linear association with BP in a cross-sectional analysis (P < 0.001), analysis of repeated measured BP values identified baseline Na/K * time interaction, i.e., an intraindividual effect, as an inverse determinant (F = 76.9, P < 0.001) independently of hypertension status and fasting conditions possibly due to regression to the mean of temporary high baseline Na/K values at baseline. Spot urine Na/K values were found to be positively associated with renal function in a cross-sectional an...Continue Reading

References

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Citations

Sep 6, 2019·Neurourology and Urodynamics·Yasuharu TabaraUNKNOWN Nagahama study group
Dec 4, 2019·Physiological Reviews·Ewout J HoornRobert A Fenton
Aug 17, 2020·International Journal of Environmental Research and Public Health·Hiroko HattoriTomonori Okamura
Jul 7, 2020·EFSA Journal·UNKNOWN EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA)Androniki Naska
Jan 5, 2021·Clinical Kidney Journal·Kuang-Yu WeiEwout J Hoorn
Apr 22, 2018·Diabetes Research and Clinical Practice·Kaori IkedaUNKNOWN Nagahama Study Group
Apr 4, 2020·Diabetes Research and Clinical Practice·Naomi TakahashiUNKNOWN Nagahama Study Group
Aug 28, 2021·Nutrients·Massimo CirilloMartino Laurenzi
Oct 26, 2021·Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine·Naomi TakahashiKazuo Chin
Sep 5, 2021·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Yuta MatsukumaTakanari Kitazono

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