Prognostic significance of SRSF2 mutations in myelodysplastic syndromes and chronic myelomonocytic leukemia: a meta-analysis

Hematology
Pourya Arbab JafariAmir Asghari

Abstract

Serine/arginine-rich splicing factor 2 (SRSF2) mutations were detected frequently in myelodysplastic syndrome (MDS) and chronic myelomonocytic leukemia (CMML) patients. However, its prognostic value has not yet been fully clarified. In this meta-analysis, Hazard Ratio (HR) and 95% confidence interval (CI) for overall-survival (OS) were chosen to evaluate the prognostic impact of SRSF2 mutations and to compare SRSF2 mutations to those with wild-type. A total of 2056 patients from 12 studies were obtained. The pooled HRs for OSsuggested that patients with MDS had a poorer prognosis (HR = 1.780, 95% CI (1.410-2.249)), while analysis on SRSF2 mutations revealed no significant effect on the prognosis of CMML patients (HR = 1.091, 95% CI (0.925-1.286)). The frequency of SRSF2 mutations was found to be 11.5% and 39.8% in patients with MDS and CMML, respectively. This meta-analysis suggests that SRSF2 has a poor prognosis in patients with MDS, but no prognosis impact on patients with CMML. In conclusion, SRSF2 mutations were significantly related to the shorter OS in patients with MDS which may consider as an adverse prognostic risk factor. Whereas, analysis did not show any prognostic effect on OS of CMML patients with SRSF2 mutations.

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Citations

Mar 15, 2019·Journal of Internal Medicine·M Tobiasson, A O Kittang
Oct 2, 2019·British Journal of Haematology·Travis P SpauldingMichael R Savona
Nov 25, 2019·Current Hematologic Malignancy Reports·David M Swoboda, David A Sallman
Feb 29, 2020·International Journal of Molecular Sciences·Toshihiko TakeiwaSatoshi Inoue
Jul 1, 2020·Frontiers in Cell and Developmental Biology·Andrea CerasuoloMaria Lina Tornesello
Apr 19, 2020·Nature Reviews. Clinical Oncology·Sophie C BonnalJuan Valcárcel
Dec 19, 2020·Leukemia & Lymphoma·Ami B Patel, Michael W Deininger
Nov 10, 2020·Leukemia & Lymphoma·Gráinne O'BrienChristophe Badie
Dec 5, 2020·Expert Review of Hematology·Thomas P ThomopoulosVasiliki Pappa
Jan 28, 2021·American Journal of Hematology·Daniel R RichardsonJoshua F Zeidner
Feb 25, 2021·Signal Transduction and Targeted Therapy·Yuanjiao ZhangYe Yang

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