Prognostic significance of SUVmax (maximum standardized uptake value) measured by [¹⁸F]FDG PET/CT in endometrial cancer.

European Journal of Nuclear Medicine and Molecular Imaging
Kazuhiro KitajimaKazuro Sugimura

Abstract

To determine if the preoperative maximum standardized uptake value (SUVmax) measured by [(18)F]FDG PET/CT has prognostic value in patients with endometrial cancer. A total of 57 patients with FIGO stage I-IV endometrial cancer underwent FDG PET/CT imaging before radical surgery. SUVmax of the primary tumour was compared with histological prognostic factors, and the relationship between SUVmax and recurrence was examined. The median duration of follow-up was 33.1 months (range 4 to 68 months). SUVmax was significantly higher in patients with a higher FIGO stage (p = 0.0015), higher tumour histological grade (p < 0.0001), myometrial invasion (p = 0.0020), larger tumour size (p = 0.0056) and lymph node metastasis (p = 0.027). Univariate analysis showed that SUVmax (uncategorized value), FIGO stage, tumour histological grade, lymph node metastasis and lymphovascular space invasion were significantly associated with recurrence. However, multivariate analysis showed that only SUVmax (p = 0.045, hazard ratio 1.11, 95% CI 1.0028-1.231) was significantly associated with recurrence. Based on ROC curve analysis and log-rank tests, patients with a high a SUVmax (≥ 12.7) had a significantly lower disease-free survival rate than those with a...Continue Reading

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Citations

Sep 13, 2012·European Journal of Nuclear Medicine and Molecular Imaging·Keiichiro NakamuraYuji Hiramatsu
Oct 1, 2013·Gynecologic Oncology·Robert FruscioCristina Messa
Apr 30, 2014·European Journal of Nuclear Medicine and Molecular Imaging·Hyun Hoon ChungYong Sang Song
Apr 3, 2015·European Journal of Nuclear Medicine and Molecular Imaging·Kazuhiro KitajimaKazuro Sugimura
Sep 10, 2013·Radiologic Clinics of North America·Jacqueline Brunetti
Jun 6, 2014·Ultrasound Quarterly·Neeraj LalwaniCarolyn M Zelop
Aug 23, 2017·European Journal of Nuclear Medicine and Molecular Imaging·Hyun Hoon ChungYong Sang Song
Nov 7, 2017·Current Oncology Reports·Sairah R KhanTara D Barwick
Aug 24, 2017·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Annette Aamand LundSøren Hess
Dec 26, 2013·Clinical Nuclear Medicine·Niklas BreuerFrederik A Verburg
Jun 9, 2015·Clinical Nuclear Medicine·Mauro SignorelliCristina Messa
Oct 27, 2020·Nuklearmedizin. Nuclear Medicine·Adnan BudakMehmet Ozeren
Feb 5, 2013·Gynecologic Oncology·Sofie Leisby AntonsenClaus Høgdall
Aug 15, 2015·Journal of Nuclear Medicine Technology·Go AkamatsuMichio Senda
Jan 30, 2016·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Vikram Rao BollineniIngfrid Haldorsen
Jun 27, 2021·Revista Española De Medicina Nuclear E Imagen Molecular·Edel Noriega-ÁlvarezÁngel M Soriano Castrejón
Aug 17, 2021·Radiologic Clinics of North America·Saul N FriedmanFarrokh Dehdashti

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