Prognostic significance of TCF21 mRNA expression in patients with lung adenocarcinoma

Scientific Reports
Jian XiaoQiong Chen

Abstract

Several prognostic indicators have shown inconsistencies in patients of different genders with lung adenocarcinoma, indicating that these variations may be due to the different genetic background of males and females with lung adenocarcinoma. In this study, we first used the Gene-Cloud of Biotechnology Information (GCBI) bioinformatics platform to identify differentially expressed genes (DEGs) that eliminated gender differences between lung adenocarcinoma and normal lung tissues. Then, we screened out that transcription factor 21 (TCF21) is a hub gene among these DEGs by creating a gene co-expression network on the GCBI platform. Furthermore, we used the comprehensive survival analysis platforms Kaplan-Meier plotter and PrognoScan to assess the prognostic value of TCF21 expression in lung adenocarcinoma patients. Finally, we concluded that decreased mRNA expression of TCF21 is a predictor for poor prognosis in patients with lung adenocarcinoma.

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Datasets Mentioned

BETA
GSE10072
19
GSE31210
GSE40791

Methods Mentioned

BETA
glycosylation

Software Mentioned

- Cloud of Biotechnology Information ( GCBI
PrognoScan
GCBI
Gene

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