Prognostic significance of the early course of minimal change nephrotic syndrome: report of the International Study of Kidney Disease in Children.

Journal of the American Society of Nephrology : JASN
P TarshishC M Edelmann

Abstract

The ability to predict the course in children with newly diagnosed minimal change nephrotic syndrome (MCNS) may have significant therapeutic implications. Previous attempts based on data available at disease onset have not been successful. Therefore, it was investigated whether characterization of the initial response to adrenocortical steroids and the course during the early months of disease are predictive of the subsequent outcome. Three hundred-eighty-nine children with MCNS, diagnosed at onset, were treated with standard prednisone regimens and monitored for up to 17 yr (mean, 9.4 yr). They were classified, after 8 wk of therapy, as initial responders (complete remission) or initial nonresponders (continued proteinuria). Subsequent classifications included nonrelapsers, infrequent relapsers, and frequent relapsers. At 8 yr of follow-up, 80% of patients were in remission. Three-fourths of initial responders who remained in remission during the first 6-month period after initial therapy (nonrelapsers; 40% of the entire series) either continued in remission during their entire course or relapsed rarely. In contrast, initial relapsers, both frequent and infrequent, achieved a nonrelapsing course only after an average of 3 yr. ...Continue Reading

Citations

Jun 16, 1999·Kidney International. Supplement·J M Bargman
Mar 4, 2015·Pediatrics in Review·Tecile Prince Andolino, Jessica Reid-Adam
Jun 23, 2020·Pediatric Research·Shoji TsujiKazunari Kaneko
Mar 6, 2021·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Federica ZottaFrancesco Emma
Feb 7, 2001·Journal of the American Society of Nephrology : JASN·Arno FuchshuberFriedhelm Hildebrandt
Jun 5, 2002·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Rashmi KirpekarRichard K Sibley
Mar 4, 2003·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Fadi FakhouriPatrick Niaudet
May 31, 2003·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Masahiro HiraokaUNKNOWN West Japan Cooperative Study Group of Kidney Disease in Children
Jun 7, 2021·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Rasmus EhrenUNKNOWN German Society for Pediatric Nephrology
Aug 29, 2003·Lancet·Allison A Eddy, Jordan M Symons
Aug 19, 2003·Pharmacotherapy·Renee F RobinsonDonald L Batisky
May 26, 2004·Clinical Science·José G van den Berg, Jan J Weening
Aug 18, 2005·Kidney International·Jung Sue KimV Matti Vehaskari
Jun 9, 2005·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Inna NovakHoward Trachtman
Aug 30, 2005·The Journal of Pediatrics·Eva-Maria RüthThomas J Neuhaus
Apr 29, 2003·Paediatric Drugs·Elisabeth Hodson
Jun 22, 2005·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Elisabeth M HodsonNarelle S Willis
Jul 1, 2006·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Mona KhuranaAsher D Schachter
Sep 13, 2006·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Aleksandra Krasowska-KwiecieńAnna Moczulska
Aug 26, 2006·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Rodney D GilbertSusan Rigden
Mar 4, 2021·Pediatrics International : Official Journal of the Japan Pediatric Society·Shoji Tsuji, Kazunari Kaneko
May 3, 2007·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Henriette A C KyrieleisJack F M Wetzels
Aug 10, 2007·Journal of the American Society of Nephrology : JASN·Aya NakajoKunimasa Yan
Sep 19, 2007·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Antonia PeñaMercedes Navarro
Feb 1, 2003·Indian Journal of Pediatrics·Sushmita Banerjee
Nov 15, 2007·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Peter SchwadererStefanie Weber
Aug 29, 2021·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Mohammad Al-MousilyKatherine Twombley
Jan 22, 2008·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Olivia BoyerMichael J G Somers
Apr 28, 2001·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·J N Sheu, J H Chen
Mar 12, 2008·Current Opinion in Pediatrics·Elisabeth M Hodson, Stephen I Alexander
Apr 1, 2003·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Bruce Z MorgensternTimothy S Larson
Mar 28, 2008·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Elisabeth M Hodson, Jonathan C Craig
Jul 16, 2008·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Eiske M DorresteijnAlbert J van der Heijden
Jun 21, 2008·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Mukta MantanArvind Bagga
Nov 18, 2008·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Yuka IkeuchiAkihiro Morikawa
Mar 4, 2009·Pediatrics in Review·Roberto Gordillo, Adrian Spitzer

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation
Masaru NakayamaSatoru Fujimi
Saudi Journal of Kidney Diseases and Transplantation : an Official Publication of the Saudi Center for Organ Transplantation, Saudi Arabia
S N Colattur, S M Korbet
© 2021 Meta ULC. All rights reserved