PMID: 488922Sep 1, 1979Paper

Prognostic significance of the histological features of malignant melanoma

Histopathology
V J McGovernG A Farago

Abstract

A review of 694 patients with localized cutaneous malignant melanoma (clinical stage I) revealed that three histological features of the primary lesion had no effect of their own on survival rate but derived their prognostic significance only because of their close correlation with tumour thickness. Primary lesions of superficial spreading histogenetic type, or of low mitotic activity or showing evidence of partial regression appeared to have a more favourable prognosis than lesions of nodular histogenetic type or of high mitotic activity or showing no regression. However, the former three histological features were predominant in thin lesions which had a better prognosis than thicker lesions. It was concluded that these features exerted only an indirect effect upon survival, tumour thickness being the most important prognostic determinant.

References

Aug 6, 1977·Lancet·J D Everall, P M Dowd
Feb 1, 1977·The Australian and New Zealand Journal of Surgery·P IronsideB K Rank
Jun 1, 1978·The Australian and New Zealand Journal of Surgery·J TonakH Groitl
Jan 1, 1977·British Journal of Haematology·J Palek
Mar 1, 1978·Plastic and Reconstructive Surgery·A Breslow, S D Macht
Jun 1, 1978·Archives of Dermatology·C Schmoeckel, O Braun-Falco
Apr 1, 1975·Pathology·V J McGovern
Oct 1, 1974·American Journal of Surgery·M G Hansen, A B McCarten
Mar 1, 1969·The Journal of Pathology·A J Cochran
Sep 1, 1968·British Journal of Cancer·W J WilliamsM M Roberts

❮ Previous
Next ❯

Citations

Jan 1, 1985·Virchows Archiv. A, Pathological Anatomy and Histopathology·K Søndergaard, G Schou
Sep 1, 1989·World Journal of Surgery·F GhussenW Groth
Jan 1, 1993·British Journal of Plastic Surgery·J C Briggs, H S Rigby
Jun 1, 1995·British Journal of Plastic Surgery·J J KirkpatrickP L Townsend
Feb 23, 1980·Lancet·I D Young, P S Harper
Feb 23, 1980·Lancet·J C Briggs
Apr 1, 1988·Annals of Surgery·S M KheirJ S Coon
Apr 1, 1994·The British Journal of Ophthalmology·A D ParidaensJ L Hungerford
Sep 17, 1983·British Medical Journal·R W Griffiths, J C Briggs
Nov 19, 1983·British Medical Journal·R H Griffiths, J C Briggs
Jan 1, 1983·Journal of Clinical Pathology·I JeffreyD Pinto
Mar 1, 1990·Postgraduate Medical Journal·M Winslet, J Tejan
Mar 2, 2002·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·S RetsasK MacRae
Nov 15, 1990·International Journal of Cancer. Journal International Du Cancer·Y ShimizuT L Whiteside
Jan 1, 1989·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·C LindholmB Tribukait
Nov 1, 1980·Journal of the American Academy of Dermatology·C M Balch
Dec 20, 2008·Clinics in Dermatology·Michael J PayetteJane M Grant-Kels
Aug 1, 1986·Journal of the American Academy of Dermatology·G S RogersD F Roses
Mar 1, 1983·Journal of the American Academy of Dermatology·H TrauR J Friedman
Jun 1, 1983·Journal of the American Academy of Dermatology·J C Maize
May 28, 2010·Journal of Cutaneous Pathology·David E Elder
Mar 7, 2014·The British Journal of Dermatology·A C de WaalW A M Blokx
Dec 18, 2007·Seminars in Oncology·Spyros Retsas, Michael J Mastrangelo
May 1, 1995·Journal of the American Academy of Dermatology·T M JohnsonA Chang
Oct 1, 1985·American Journal of Surgery·J E WoodsE J Bergstralh
Feb 1, 1983·European Journal of Cancer & Clinical Oncology·C SchmoeckelO Braun-Falco

❮ Previous
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