Prognostic significance of the lymph node ratio regarding recurrence and survival in rectal cancer patients treated with postoperative chemoradiotherapy.

Gut and Liver
Ji-Yoon KimMi-Ryeong Ryu

Abstract

TO EVALUATE THE PROGNOSTIC IMPACT OF THE LYMPH NODE RATIO (LNR: the ratio of positive lymph nodes to the total number of lymph nodes examined) on disease recurrence and survival among rectal cancer patients who received curative surgery and postoperative chemoradiotherapy (CRT). Between 1995 and 2008, 124 patients with pathologic T3-4 or node-positive rectal cancer underwent curative surgery and postoperative CRT. Postoperative radiotherapy was delivered at a median dose of 50.4 Gy (range, 45 to 59.4 Gy) for 6 weeks. Chemotherapy consisted of a bolus injection of 5-fluorouracil and leucovorin in the first and last week of radiotherapy (91.9%) or daily capecitabine during radiotherapy (8.1%). Further adjuvant chemotherapy was administered after chemoradiation. The median follow-up was 5.1 years. In the multivariate analysis, pathologic N (pN) stage and lymphovascular invasion were significantly associated with disease-free survival and disease-specific survival (p<0.05). However, when the LNR with a cutoff value of 0.2 was included as a covariate in the model, the LNR was highly significant (p<0.001), and the pN stage lost its significance (p>0.05). The LNR predicts recurrence and survival more accurately than pN stage. The pN s...Continue Reading

References

Feb 7, 2002·Annals of Surgical Oncology·Kentaro InoueKoshiro Hioki
Sep 1, 2004·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·C C ThornN S Ambrose
Oct 22, 2004·The New England Journal of Medicine·Rolf SauerUNKNOWN German Rectal Cancer Study Group
Jan 29, 2008·Journal of the American College of Surgeons·Alexander J GreensteinJuan P Wisnivesky
Dec 19, 2008·Annals of Surgery·Frédérique PeschaudBernard Nordlinger
Jan 24, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Vincent Vinh-HungChristine Bouchardy
Mar 18, 2009·International Journal of Radiation Oncology, Biology, Physics·Young Seok KimHeung Moon Chang
Aug 8, 2009·The American Journal of Surgical Pathology·Leonie J M MekenkampUNKNOWN Pathology Review Committee and the Co-operative Clinical Investigators
Apr 22, 2011·Cancer Research and Treatment : Official Journal of Korean Cancer Association·Kyu-Won JungJin-Soo Lee
May 24, 2011·Journal of the Korean Society of Coloproctology·Tai Young OhSun Hoo Park

❮ Previous
Next ❯

Citations

Apr 16, 2013·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·M La TorreV Ziparo
Dec 19, 2013·Head & Neck·Yong-Hong HuaZhen-Fu Fu
Apr 30, 2016·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·D LeonardA Kartheuser

❮ Previous
Next ❯

Methods Mentioned

BETA
dissection

Software Mentioned

SPSS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.