Prognostic significance of the programmed death ligand 1 expression in clear cell renal cell carcinoma and correlation with the tumor microenvironment and hypoxia-inducible factor expression

Diagnostic Pathology
Hayriye Tatli DoganBerrak Gumuskaya

Abstract

Clear cell renal cell carcinoma (ccRCC) is the most common renal malignancy. Hypoxia-inducible factors, HIF-1α and HIF-2α, are expressed in the majority of ccRCC. Targeting immune checkpoints with the blockade of PD-1 and its ligand PD-L1 reorganizes T-cell activity in tumor microenvironment and provides important antitumor responses. PD-L1 upregulation has been found to be hypoxia-inducible factor (HIF) dependent. Our aim is to demonstrate the association between PD-L1 and HIF expression and to reveal the role of PD-L1 in prognosis and its association with tumor microenvironment. Surgical specimens from 145 patients diagnosed with ccRCC, who had undergone radical or partial nephrectomy, were retrospectively analyzed. Immunohistochemistry on tissue microarrays (TMA) was performed to demonstrate expressions of PD-L1, HIF-1α, and HIF-2α in tumor cells and PD-1, CD4, and CD8 in lymphocytes to assess lymphocyte density in tumor microenvironment. PD-L1 tumor cell expression was detected in 20/125 (13.8%) cases, which correlated with higher levels of PD-1, CD4, CD8 and HIF-2α expression. Low or high expression of HIF-1α was similar in PD-L1-positive cases. When PD-L1-positive cases were compared with negative ones, there was no signi...Continue Reading

References

Dec 1, 2004·Proceedings of the National Academy of Sciences of the United States of America·R Houston ThompsonEugene D Kwon
Dec 13, 2006·The Journal of Urology·Victoria A RobbElizabeth P Henske
Mar 17, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·R Houston ThompsonEugene D Kwon
Apr 17, 2007·Current Opinion in Immunology·Mary E KeirArlene H Sharpe
Mar 13, 2010·The Journal of Pathology·Marcella M BaldewijnsAdriaan P de Bruïne
Mar 1, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Xavier FrigolaEugene D Kwon
Dec 16, 2011·Nature Reviews. Cancer·Brian KeithM Celeste Simon
Mar 9, 2012·The New England Journal of Medicine·Marco GerlingerCharles Swanton
Dec 18, 2013·Cancer Research·Ivraym B BarsoumCharles H Graham
Apr 30, 2014·The Journal of Experimental Medicine·Muhammad Zaeem NomanSalem Chouaib
Oct 26, 2014·Cancer Research·Ivraym B BarsoumCharles H Graham
Nov 12, 2014·Annual Review of Pathology·Ian J Frew, Holger Moch
Dec 30, 2014·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Toni K ChoueiriRobert J Motzer
Jan 15, 2015·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Benoit BeuselinckJessica Zucman-Rossi
Feb 20, 2015·Molecular Cancer Therapeutics·Sandip Pravin Patel, Razelle Kurzrock
May 28, 2015·Cancer Immunology Research·Marcella CalleaSabina Signoretti
Sep 26, 2015·The New England Journal of Medicine·Robert J MotzerUNKNOWN CheckMate 025 Investigators
Oct 17, 2015·Diagnostic Pathology·Katia R M LeiteMiguel Srougi
Mar 8, 2016·International Journal of Cancer. Journal International Du Cancer·Melanie RufPeter Schraml
Nov 4, 2016·Nature·Wenfang ChenJames Brugarolas
Sep 14, 2016·International Journal of Cancer. Journal International Du Cancer·Solène-Florence Kammerer-JacquetNathalie Rioux-Leclercq
Feb 19, 2017·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Nicolas A GiraldoCatherine Sautès-Fridman

❮ Previous
Next ❯

Citations

Jan 16, 2019·Current Urology Reports·Caroline E Nunes-XavierJosé I López
Feb 9, 2019·Advanced Healthcare Materials·Yuta AndoKeyue Shen
May 14, 2019·Expert Review of Molecular Diagnostics·Ke MaYuyang Zhang
Aug 25, 2019·Cancers·Javier C Angulo, Oleg Shapiro
May 23, 2019·Current Opinion in Clinical Nutrition and Metabolic Care·Andrew RedfernErik W Thompson
Feb 27, 2021·Analytical and Bioanalytical Chemistry·Cristina Muñoz-San MartínSusana Campuzano
Mar 28, 2020·Current Drug Targets·Kerstin JunkerRodolfo Montironi

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsies

Software Mentioned

MS
SPSS Statistics
Excel
SPSS

Related Concepts

Related Feeds

Adenocarcinoma, Clear Cell

Clear Cell Adenocarcinoma is a tumor that arises in the female genital tract and is characterized by cells that appear clear under the microscope. Discover the latest research here.