Prognostic significance of the radiologic features of pneumonitis induced by anti-PD-1 therapy

Cancer Medicine
Satoshi WatanabeToshiaki Kikuchi

Abstract

Interstitial lung disease (ILD) induced by anti-programmed-cell death-1 (PD-1) and anti-PD-ligand 1 (PD-L1) is potentially life-threatening and is a common reason of the discontinuation of therapy. In contrast, an enhancement in antitumor effects was reported in patients who developed immune-related adverse events, including ILD. Although recent evidence suggests that radiologic patterns of ILD may reflect the severity of ILD and the antitumor immune responses to anti-PD-1/PD-L1 therapies, the association between radiologic features and clinical outcomes remains unclear. Patients with advanced non-small-cell lung cancer who were treated with 1st to 3rd line anti-PD-1 therapy from January 2016 through October 2017 were identified at multiple institutions belonging to the Niigata Lung Cancer Treatment Group. ILD was diagnosed by the treating physicians, and chest computed tomography scans were independently reviewed to assess the radiologic features of ILD. A total of 231 patients who received anti-PD-1 therapy were enrolled. Thirty-one patients (14%) developed ILD. Sixteen patients were classified as having ground glass opacities (GGO), 16 were classified as having cryptogenic organizing pneumonia (COP), and one was classified a...Continue Reading

References

May 23, 2014·Insights Into Imaging·Stefano PalmucciCarlo Vancheri
Jun 2, 2015·The New England Journal of Medicine·Julie BrahmerDavid R Spigel
Sep 29, 2015·The New England Journal of Medicine·Hossein BorghaeiJulie R Brahmer
Jan 3, 2016·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Kazuhisa NakashimaToshiaki Takahashi
Jan 14, 2016·Japanese Journal of Clinical Oncology·Tasuku SanoRyuhei Okuyama
Aug 19, 2016·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Mizuki NishinoF Stephen Hodi
Sep 21, 2016·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jarushka NaidooMatthew D Hellmann
Oct 11, 2016·The New England Journal of Medicine·Martin ReckUNKNOWN KEYNOTE-024 Investigators
Jan 11, 2018·The New England Journal of Medicine·Michael A PostowMatthew D Hellmann
Apr 17, 2018·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Daichi FujimotoToyohiro Hirai
Jun 24, 2018·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Susan C Scott, Nathan A Pennell
Dec 7, 2018·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Karthik SureshJarushka Naidoo

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Citations

Dec 5, 2020·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Larissa B CostaCarlos A Buchpiguel

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