Prognostic significance of the thymidylate biosynthetic enzymes in human colorectal tumors

Oncology
Judit KralovánszkyA Jeney

Abstract

The aim of the present study was to determine the relative intratumoral activity of two pyrimidine biosynthetic enzymes, i.e. thymidylate synthase (TS) and thymidine kinase (TK), in human colorectal cancers to compare their possible relationship with demographic and pathologic characteristics of the patients and their tumors, and moreover to evaluate their predictive significance regarding 5-fluorouracil (5-FU) sensitivity and the overall survival of patients, respectively. TS and TK levels were significantly increased in the tumor compared to peritumoral tissue. However, no significant relationship between TS/TK activity and demographic features of the patients or pathologic characteristics of their tumors could be demonstrated. Kaplan-Meier analysis showed that the overall survival of patients with low TS activity was significantly longer (p < 0.012) compared to those with high TS activity. Such a difference could not be demonstrated between patients with high or low TK activity; however, combined evaluation of the two parameters proved that TK may contribute to the more precise assessment of disease prognosis, and it may further influence treatment decisions, i.e. the selection of patients for adjuvant therapy with 5-FU and ...Continue Reading

Citations

Jan 15, 2008·Pharmacogenetics and Genomics·Georg LurjeHeinz-Josef Lenz
Sep 12, 2002·Pharmacogenomics·Thomas Seufferlein, Bernhard O Boehm
Apr 12, 2008·Magyar onkologia·Judit Kralovánszky
Jan 19, 2008·World Journal of Gastroenterology : WJG·Kai-Huan YuZe-Sheng Wang
Aug 24, 2013·Genetic Testing and Molecular Biomarkers·Violetta Sulzyc-BielickaMarek Drozdzik
Apr 25, 2007·Scandinavian Journal of Gastroenterology·Riyad BendardafSeppo Pyrhönen
Oct 12, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Julie L EisemanRaymond W Klecker
Apr 23, 2009·Molecular Cancer Therapeutics·Georg LurjeHeinz-Josef Lenz
Mar 26, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·John BoyerPatrick G Johnston
Feb 5, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Kazumi UchidaPeter V Danenberg

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