Prognostic significance of TIMP-2, MMP-2, and MMP-9 on high-grade serous ovarian carcinoma using digital image analysis

Human Pathology
Patrice DesmeulesIsabelle Bairati

Abstract

The objective of this cohort study was to evaluate whether the immunohistochemical expression of tissue inhibitor of metalloprotease 2, matrix metalloproteinase (MMP) 2, and MMP-9 could predict the occurrence of death and progression in women with ovarian high-grade serous carcinoma (HGSC). A total of 100 women with primary HGSC who were treated by cytoreductive surgery and adjuvant chemotherapy at the Centre Hospitalier Universitaire de Québec (Canada) were included. Biomarker expression was evaluated by immunohistochemistry on tissue microarrays constructed from primary tumors. Immunostaining quantification was performed using digital image analysis, from algorithms created with Calopix software, and continuous H-score data were obtained. The cancer antigen-125 and/or the Response Evaluation Criteria In Solid Tumors criteria were used to define progression. Dates of death were obtained by record linkage with the Québec mortality files. Hazard ratios (HRs) of death and progression with their 95% confidence intervals (CIs) were estimated using the Cox proportional hazards regression model. Overall, a low variability of expression was observed for each marker. No association was found between the level of expression and standard...Continue Reading

References

Sep 30, 1999·Gynecologic Oncology·A WesterlundT Turpeenniemi-Hujanen
May 4, 2002·Molecular and Cellular Endocrinology·Ben DavidsonReuven Reich
Sep 13, 2003·Molecular Human Reproduction·Tomomitsu OkamotoSatoru Yamada
Mar 23, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Aparna A KamatAnil K Sood
Nov 30, 2006·Molecular Carcinogenesis·Kathy Qi CaiXiang-Xi Xu
Dec 23, 2008·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·E A EisenhauerJ Verweij
Sep 10, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Roopali RoyMarsha A Moses
Jan 9, 2010·Gynecologic Oncology·Valentina GuarneriPier Franco Conte
Aug 23, 2011·Recent Patents on Anti-cancer Drug Discovery·Zheng-gao ShiXun Li
Apr 19, 2012·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Agnieszka HałońPawel Surowiak
Apr 4, 2013·Critical Reviews in Biochemistry and Molecular Biology·Jennifer VandoorenGhislain Opdenakker
Sep 3, 2013·Asian Pacific Journal of Cancer Prevention : APJCP·Li-Na LiJun Yan
Jan 9, 2014·CA: a Cancer Journal for Clinicians·Rebecca SiegelAhmedin Jemal
Mar 8, 2014·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Dominique TrudelBernard Têtu
May 27, 2014·Frontiers in Oncology·Ben DavidsonReuven Reich
Nov 5, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Alan P Venook, Josep Tabernero

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Citations

Apr 22, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Changmei Liu, Fangmei Yang
Feb 3, 2018·International Journal of Molecular Sciences·Ruth M EscalonaNuzhat Ahmed
Apr 4, 2018·PloS One·Xiaoyang ZhangZhi-Liang Lu
May 18, 2019·The Journal of International Medical Research·Linchai ZengHaiyan Zhu
Jul 3, 2019·The Biochemical Journal·Vasily RybakinGhislain Opdenakker
Jan 7, 2018·Journal of Ovarian Research·Aneta Cymbaluk-PłoskaAgnieszka Sompolska-Rzechuła
Nov 2, 2019·Nanomedicine : Nanotechnology, Biology, and Medicine·Alessandro MarturanoPaolo Gresele

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