Prognostic significance of tumor-infiltrating lymphocytes in patients with operable tongue cancer

Radiation Oncology
Wan-Yu ChenAnn-Lii Cheng

Abstract

Our aim was to investigate the prognostic significance of tumor-infiltrating lymphocytes (TILs) in operable tongue cancer patients. The presence of CD3+, CD4+, CD8+, and forkhead box protein P3-positive (FOXP3+) TILs in tumor tissues obtained from 93 patients during surgery was examined using immunohistochemistry. The 3-year overall survival (OS) of patients with a low CD8/FOXP3 ratio was significantly lower than that of patients with a high CD8/FOXP3 ratio (63.8% vs. 87.3%, p = 0.001). Patients with high FOXP3 had a significantly lower 3-year regional recurrence-free survival (RRFS) than did patients with low FOXP3 (49.3% vs. 87.3%, univariate log rank p = 0.000). A low CD4/FOXP3 ratio (68.4% vs. 93.7%, univariate log rank p = 0.002) was significantly unfavorable prognostic factors for 3-year distant metastasis-free survival (DMFS). In addition to clinicopathological characteristics, TIL markers represent prognosticators for clinical outcomes.

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Citations

Dec 12, 2018·The Journal of Immunology : Official Journal of the American Association of Immunologists·Melanie BoxbergAndreas Kolk
Jul 20, 2019·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Zhengxian HuangCheng Wang
Mar 14, 2020·Cancer Science·Kazushige KoikeAkihiro Miyazaki
May 12, 2020·European Radiology Experimental·R C BakkerJ F W Nijsen
Apr 28, 2020·Laryngoscope Investigative Otolaryngology·Hassan Nasser, Maie A St John
Sep 29, 2020·Cancer Management and Research·Yenlin HuangKai-Ping Chang
Jul 1, 2020·Current Oncology Reports·Niels E WondergemRieneke van de Ven

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