Prognostic significance of urokinase-type plasminogen activator and plasminogen activator inhibitor-1 in primary breast cancer

British Journal of Cancer
A KnoopC Rose

Abstract

The uPA-mediated pathway of plasminogen activation is central to cancer metastasis. Whether uPA and PAI-1 are related to local recurrence, metastatic spread or both is not clear. We present a retrospective study of 429 primary breast cancer patients with a median follow-up of 5.1 years, in which the levels of uPA and PAI-1 in tumour extracts were analysed by means of an enzyme-linked immunosorbent assay. The median values of uPA and PAI-1, which were used as cut-off points, were 4.5 and 11.1 ng mg(-1) protein respectively. The levels of uPA and PAI-1 were correlated with tumour size, degree of anaplasia, steroid receptor status and number of positive nodes. Patients with high content of either uPA or PAI-1 had increased risk of relapse and death. We demonstrated an independent ability of PAI-1 to predict distant metastasis (relative risk 1.7, confidence limits 1.22 and 2.46) and that neither uPA nor PAI-1 provided any information regarding local recurrence.

Citations

Jan 7, 2004·Nature Reviews. Cancer·Jeffrey W Pollard
Sep 29, 2012·Clinical Chemistry·Maria P PavlouIvan M Blasutig
Mar 5, 1999·Breast Cancer Research and Treatment·D G Altman, G H Lyman
Jul 2, 1999·Journal of Surgical Oncology·M J DuffyN O'Higgins
May 23, 2002·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Haiying ZhaoKeisuke Izumi
May 29, 2000·Journal of Gastroenterology and Hepatology·T ItohH Itoh
Aug 15, 2002·The Journal of Biological Chemistry·Diane PalmieriFrank C Church
Apr 3, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·P MalmströmUNKNOWN South Sweden Breast Cancer Group
Oct 8, 2005·Advances in Anatomic Pathology·Sharon Nofech-MozesWedad Hanna
Aug 19, 2007·Annals of Surgical Oncology·Thelma C HurdJohn F Gibbs
Apr 25, 2006·The Journal of Biological Chemistry·Daniela AlfanoM Patrizia Stoppelli
Dec 3, 2008·The Journal of Biological Chemistry·Grant E BlousePeter A Andreasen
Aug 13, 2010·Biomarkers in Medicine·Rudolf NapieralskiManfred Schmitt
Oct 3, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·C BouchetF Spyratos
Apr 6, 1999·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·M P Look, J A Foekens
May 20, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M E Meijer-van GelderJ A Foekens
Jul 27, 2007·Acta Oncologica·Birgitte Vrou OffersenUNKNOWN Danish Breast Cancer Cooperative Group (DBCG) Tumor Biology Committee
Feb 14, 2015·Breast Cancer Research : BCR·Michael J DuffyManfred Schmitt
Apr 1, 2014·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Xiao-song YangDong-xu Liu
Nov 18, 2019·Cancer Metastasis Reviews·Marta Helena Kubala, Yves Albert DeClerck
Nov 18, 2017·Acta Oncologica·Cai GrauJens Overgaard
Feb 24, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Takumi SakakibaraAkimasa Nakao
Apr 11, 2006·Molecular Cancer Research : MCR·Haitian LuChuanshu Huang
May 18, 2021·EMBO Molecular Medicine·Bernd UhlChristoph A Reichel
Jun 2, 2006·Cancer Cell International·Britny J CandiaRobert A Orlando
Oct 22, 2010·RNA·Daniel Miotto DupontPeter André Andreasen

❮ Previous
Next ❯

Related Concepts

Related Feeds

Breast Invasive Carcinoma

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Breast Invasive Carcinoma (Keystone)

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.