Prognostic significance of vascular endothelial growth factor expression in ovarian cancer patients: a long-term follow-up

International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society
C RudlowskiW Schroeder

Abstract

The purpose of the study was to determine vascular endothelial growth factor (VEGF) concentrations in ascites from ovarian cancer and to correlate these data with VEGF expression in ovarian tumors, serum VEGF concentrations, and clinicopathologic characteristics. Ascites, serum, and tumor tissue from 65 ovarian carcinomas and eight borderline tumors were collected. VEGF concentration in peritoneal fluids and sera was determined using enzyme immunoassay. VEGF tumor expression was evaluated immunohistochemically. Significantly higher VEGF concentrations were found in ascites from malignant tumors (median, 2575 pg mL(-1)) compared with borderline tumors (median 181.9 pg mL(-1)) and benign peritoneal fluid (184.5 pg mL(-1)). Both VEGF ascites concentration and tumor expression correlated with advanced tumor stages and ascites volume. Elevated VEGF ascites levels were negatively correlated to patient survival. No differences between VEGF serum levels could be observed between ovarian cancer patients and patients with benign cysts. This study showed for the first time the clinical significance of elevated VEGF ascites level in ovarian carcinomas. VEGF is expressed by ovarian tumor cells and locally released in the malignant peritonea...Continue Reading

References

Oct 1, 1991·Current Opinion in Oncology·B M Kacinski, S K Chambers
Jan 1, 1994·Progress in Growth Factor Research·G NeufeldB Z Levi
Feb 1, 1995·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·K MaedaY Arimoto
Apr 5, 1995·Journal of the National Cancer Institute·C A BoocockS K Smith
Nov 18, 1993·The New England Journal of Medicine·S A Cannistra
Sep 1, 1993·Cancer Metastasis Reviews·D R SengerH F Dvorak
Dec 1, 1996·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·N Ferrara
Dec 21, 2000·Current Oncology Reports·D A Hazelton, T C Hamilton
Feb 17, 2001·Cancer·E A BossC G Sweep
Jan 17, 2002·The Journal of Surgical Research·Carson D LiuDavid W McFadden
Jan 30, 2002·CA: a Cancer Journal for Clinicians·Ahmedin JemalMichael Thun
Jul 12, 2002·Statistics in Medicine·Norman PhillipsMary L McBride
Oct 31, 2002·Statistics in Medicine·Arduino VerdecchiaRiccardo Capocaccia
Nov 26, 2002·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·K DehavenC Gercel-Taylor
Nov 29, 2002·Molecular Pathology : MP·E S Bamberger, C W Perrett
Dec 17, 2003·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·H T SeeR C Bast

❮ Previous
Next ❯

Citations

May 12, 2010·Archives of Gynecology and Obstetrics·Solange Maria Diniz BizzoMaria Helena Faria Ornellas
Feb 23, 2012·PloS One·Julie LafontaineAnne-Marie Mes-Masson
Mar 3, 2009·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Takehiko TsuchiyaIkuo Morita
Apr 25, 2012·Critical Reviews in Oncology/hematology·Arne R M van der BiltAnna K L Reyners
May 12, 2012·Critical Reviews in Oncology/hematology·A BamiasE Pujade-Lauraine
Apr 14, 2012·Journal of Vascular and Interventional Radiology : JVIR·Florentina PascaleAlexandre Laurent
Sep 1, 2012·Translational Oncology·Tilley Jenkins VogelElizabeth M Swisher
Sep 14, 2010·Gynecologic Oncology·Felicity LoseAmanda B Spurdle
Feb 20, 2010·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Solange Maria Diniz BizzoMaria Helena Faria Ornellas
Nov 13, 2008·International Journal of Cancer. Journal International Du Cancer·Ifat SherBrenda L Coomber
Jul 14, 2012·ISRN Obstetrics and Gynecology·Elisabetta BandieraAntonella Ravaggi
Sep 4, 2010·Seminars in Cell & Developmental Biology·John FoleyDavid J Riese
May 15, 2013·Journal of the National Cancer Institute·Stacey D Finley, Aleksander S Popel
Aug 29, 2017·International Journal of Molecular Sciences·Artor Niccoli AsabellaGiuseppe Rubini
Apr 4, 2015·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Xiaolian ZhangAiping Qin
Jun 3, 2017·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Blanca González-PalomaresJose Antonio Vidart Aragon
Aug 22, 2007·Journal of Surgical Oncology·John P GeislerKelly J Manahan
Mar 15, 2014·International Journal of Oncology·Vincenza ConteducaUgo De Giorgi
Sep 27, 2018·Disease Models & Mechanisms·Yuliya KlymenkoM Sharon Stack

❮ Previous
Next ❯

Related Concepts

Related Feeds

Arterial-Venous in Development & Disease

Arterial-venous development may play a crucial role in cardiovascular diseases. Here is the latest research.

Related Papers

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Michael J GoodheartRichard E Buller
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Timothy J DuncanLindy G Durrant
© 2021 Meta ULC. All rights reserved