Prognostic significance of wound infections following major head and neck cancer surgery: an open non-comparative prospective study

Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer
Nicolas PenelJean-Louis Lefebvre

Abstract

We evaluated the incidence, risk factors and consequences of wound infection (WI) following major head and neck cancer surgery in an open non-comparative study. The study group, comprising 95 patients who underwent clean-contaminated procedures with opening of the upper aerodigestive tract for biopsy-proven squamous cell cancer, were studied over a 1-year period. Antibiotic prophylaxis was amoxicillin and clavulanic acid. More than 20 variables were prospectively recorded for each patient. The mean follow-up was 30 months. The overall WI rate was 50.5% (48/95). Most pathogens isolated from samples were gram-negative rods. In univariate analysis, we found three risk factors for WI: alcohol consumption (P = 0.07), a hypopharyngeal location (P = 0.02) and laryngectomy stoma (P = 0.01). WI were associated with postoperative fever (P = l.5 x 10(-11)), postoperative antibiotic therapy (P = 1.5 x 10(-5)) and postoperative death (P = 0.043). Patients without WI had a median postoperative hospital stay of 15 days compared with 29 days for those with WI (P < 0.001). Healing of WI was achieved after a median time of 48 days. WI delayed postoperative radiation therapy in 21 out of 33 evaluable patients. But overall survival, and local and ...Continue Reading

Citations

Apr 19, 2015·Journal of Otolaryngology - Head & Neck Surgery = Le Journal D'oto-rhino-laryngologie Et De Chirurgie Cervico-faciale·Masaya AkashiTakahide Komori
Aug 7, 2012·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Hitoshi HirakawaMikio Suzuki
Jan 24, 2012·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Chun-Yue MaWei Han
Dec 20, 2007·Oral and Maxillofacial Surgery Clinics of North America·Ladi Doonquah, Leleka Doonquah
Oct 26, 2011·Head & Neck·Rocío González-MárquezCarlos Suárez Nieto
Sep 17, 2013·Head & Neck·Maciej J MazurekArtur Włodarczyk

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