PMID: 29476046Feb 25, 2018Paper

Prognostic Significance of Zinc Finger E-Box-Binding Homeobox Family in Glioblastoma

Medical Science Monitor : International Medical Journal of Experimental and Clinical Research
Peng ChenLingling Hu

Abstract

BACKGROUND Epithelial-mesenchymal transition (EMT) is an essential progress for tumor cell invasion to both epithelial and non-epithelial cancers, and zinc finger E-box-binding homeobox 1/2 (ZEB1/2) is a well-known promoter of EMT. In glioma cell lines, both ZEB1 and ZEB2 have been demonstrated to facilitate cancer cell proliferation and invasion with experiments in vitro. However, the clinical significance of ZEB1 and ZEB2 in glioblastoma (GBM) is still controversial. MATERIAL AND METHODS We detected the expression of ZEB1 and ZEB2 in 91 cases of GBM with immunohistochemistry and investigated the correlation between clinicopathological factors and ZEB family expression with Fisher test. By univariate analysis with Kaplan-Meier test, we explored the prognostic significance of ZEB1/2 expression and the clinicopathological factors in GBM. By multivariate analysis with the Cox regression model, we identified the independent prognostic factors in GBM. RESULTS The percentages of ZEB1 high expression and ZEB2 high expression were 31.9% (29/91) and 41.9% (36/91), respectively. High expression of ZEB2 was significantly associated with lower survival rate of GBM patients (P=0.001). ZEB2, lower KPS score (P=0.004), gross total resection ...Continue Reading

Citations

Apr 17, 2019·Journal of Neuropathology and Experimental Neurology·Satoru KomakiMotohiro Morioka
Feb 13, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Sahar SafaeeBehzad Baradaran
May 29, 2021·Cellular and Molecular Neurobiology·Wei WangDi Wu

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