Prognostic stratification of patients with nasopharyngeal carcinoma based on tumor immune microenvironment

Head & Neck
Takeharu OnoHirohito Umeno

Abstract

Little is known about immune-related prognostic factors in patients with nasopharyngeal carcinoma (NPC). We retrospectively reviewed 66 patients with NPC. Epstein-Barr virus (EBV) status, programmed cell death-ligand 1 (PD-L1) expression, and tumor-infiltrating lymphocyte (TIL) densities were analyzed, and a prognostic evaluation of these immune-related parameters was performed. The multivariate analyses demonstrated that CD8-positive TIL density but not PD-L1 expression on tumor cells or immune cells was a significant predictive factor for progression-free survival (PFS) and overall survival (OS). Subgroup analyses demonstrated that a positive PD-L1 expression on tumor cells in combination with a higher CD8-positive TIL density was significantly associated with favorable prognosis, whereas positive PD-L1 expression on tumor cells with lower CD8-positive TIL density was associated with worse prognosis. Our results suggest that PD-L1 expression on tumor cells in combination with CD8-positive TIL density could be a useful predictive biomarker for risk stratification in patients with NPC.

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Citations

Mar 1, 2020·The Laryngoscope·Michael WotmanTristan Tham
Mar 20, 2020·American Society of Clinical Oncology Educational Book·Brigette B Y MaJun Ma
Oct 7, 2020·The Laryngoscope·Fumihiko SatoHirohisa Yano
Jul 8, 2020·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Lian-Zhen ZhongJie Tian
May 25, 2021·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Weixing LiuXiaowen Zhang
Jun 23, 2021·Journal of Experimental & Clinical Cancer Research : CR·Ramon YarzaLara Carmen Iglesias-Docampo
Jul 30, 2021·Technology in Cancer Research & Treatment·Birhanu Aberha BereleGuifang Yang

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