Prognostic Subgroups among Patients with Stage II Colon Cancer

The New England Journal of Medicine
C Richard Boland, Ajay Goel

Abstract

Colon cancer has traditionally been treated surgically. However, many cases of colon cancer are systemic at the time of diagnosis, and apparently curative surgery is followed at a later date by tumor recurrence as a consequence of circulating tumor cells before the surgery. Adjuvant medical therapies are designed to prevent recurrences after surgical resection. The current standard for clinical prognostication relies principally on pathological staging. In early-stage colon cancers (stages I and II), all the tumor is contained within the wall of the colon. Less than 10% of patients with stage I disease have a recurrence, and adjuvant chemotherapy is . . .

References

Jun 17, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Al B BensonDaniel G Haller
Feb 4, 2005·The New England Journal of Medicine·Jeffrey A Meyerhardt, Robert J Mayer
Jan 6, 2012·The New England Journal of Medicine·Matthias P A EbertRoland M Schmid
Jul 29, 2015·Gastroenterology·Yoshinaga OkugawaAjay Goel
Jul 29, 2015·Gastroenterology·John M Carethers, Barbara H Jung
Jan 21, 2016·The New England Journal of Medicine·Piero DalerbaMichael F Clarke

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Citations

May 1, 2018·International Journal of Colorectal Disease·Soo Young LeeHyeong Rok Kim
Sep 10, 2020·Cancer Management and Research·Yifan ZhouHuaqing Zhu
Mar 19, 2021·Acta Oncologica·Athanasios TampakisRaoul A Droeser
May 24, 2019·Human Pathology·Matthew J CecchiniDavid K Driman

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