Abstract
It is unknown whether left ventricular hypertrophy (LVH) diagnosis by electrocardiography improves risk stratification in patients with atrial fibrillation (AF). We investigated the prognostic impact of LVH diagnosis by electrocardiography in a large sample of anticoagulated patients with AF included in the Randomized Evaluation of Long-Term Anticoagulant Therapy (RE-LY) Study. We defined electrographic LVH (ECG-LVH) by strain pattern or Cornell voltage (R wave in aVL plus S wave in V3) >2.0 mV (women) or >2.4 mV (men). LVH prevalence was 22.7%. During a median follow-up of 2.0 years, 303 patients developed a stroke, 778 died (497 from cardiovascular causes), and 140 developed a myocardial infarction. LVH was associated with a greater risk of stroke (1.99% vs 1.32% per year, hazard ratio [HR] 1.51, 95% confidence interval [CI] 1.18 to 1.93, p <0.001), cardiovascular death (4.52% vs 1.80% per year, HR 2.56, 95% CI 2.14 to 3.06, p <0.0001), all-cause death (6.03% vs 3.11% per year, HR 1.95, 95% CI 1.68 to 2.26, p <0.0001), and myocardial infarction (1.11% vs 0.55% per year, HR 2.07, 95% CI 1.47 to 2.92, p <0.0001). In multivariate analysis, the prognostic value of LVH was additive to CHA2DS2-VASc score and other covariates. The c...Continue Reading
References
Mar 1, 1987·Circulation·P N CasaleP Kligfield
Feb 1, 1987·American Heart Journal·B E KregerW B Kannel
Nov 11, 1998·The American Journal of Cardiology·W B KannelD Levy
Mar 5, 1999·Heart·D De BacquerH Blackburn
Oct 24, 2001·Circulation·P VerdecchiaG Ambrosio
Jan 29, 2002·European Heart Journal·C T LarsenP Schnohr
Feb 8, 2003·Hypertension·Paolo VerdecchiaCarlo Porcellati
Aug 9, 2005·American Heart Journal·Bill P HsiehVictor F Froelicher
Feb 21, 2007·Circulation·Nancy R Cook
Jun 15, 2007·Statistics in Medicine·Michael J PencinaRamachandran S Vasan
Mar 8, 2008·Stroke; a Journal of Cerebral Circulation·Gregory Y H Lip
Apr 21, 2009·American Heart Journal·Michael D EzekowitzSalim Yusuf
Sep 1, 2009·The New England Journal of Medicine·Stuart J ConnollyUNKNOWN RE-LY Steering Committee and Investigators
Sep 19, 2009·Chest·Gregory Y H LipHarry J G M Crijns
Sep 23, 2009·Circulation·Paolo VerdecchiaUNKNOWN ONTARGET/TRANSCEND Investigators
Jan 1, 2010·The New England Journal of Medicine·Donald Stuart Houston, Ryan Zarychanski
Jul 27, 2010·The American Journal of Medicine·Gregory Y H Lip, Deirdre A Lane
Sep 30, 2010·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·A John CammUNKNOWN ESC Committee for Practice Guidelines
Jan 5, 2011·Statistics in Medicine·Michael J PencinaEwout W Steyerberg
Dec 27, 2011·European Heart Journal·Jakob RaunsøMorten Lock Hansen
Mar 1, 2012·Circulation·Ziad HijaziLars Wallentin
Jun 19, 2013·The American Journal of Cardiology·William C RobertsJamshid Shirani
Citations
Jul 18, 2015·The American Journal of Cardiology·Marco ProiettiUNKNOWN GIS Group
Jun 26, 2015·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Giuseppe BorianiUNKNOWN Document reviewers
Jul 23, 2014·The American Journal of Cardiology·Anders M GreveKristian Wachtell
May 19, 2017·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Paolo VerdecchiaGiuseppe Di Pasquale
Apr 1, 2018·Clinical Cardiology·Song-Nan LiChang-Sheng Ma
Nov 7, 2017·The Cochrane Database of Systematic Reviews·Miho KimachiShunichi Fukuhara
Dec 19, 2017·Journal of Cardiovascular Medicine·Matteo CameliUNKNOWN Società Italiana di Cardiologia, Sezione Regionale Tosco-Umbra
Jan 18, 2019·Journal of the American Heart Association·Ziad HijaziLars Wallentin
Jan 17, 2017·Current Emergency and Hospital Medicine Reports·Bory KeaMerritt Raitt
Aug 17, 2021·Frontiers in Cardiovascular Medicine·Huaqiang XiangHuifen Zhu