Prognostic utility of basaloid differentiation in oropharyngeal cancer

Journal of Otolaryngology - Head & Neck Surgery = Le Journal D'oto-rhino-laryngologie Et De Chirurgie Cervico-faciale
Timothy CooperHadi Seikaly

Abstract

Human papillomavirus (HPV) is recognized as the key risk factor for a distinct subset of oropharyngeal squamous cell carcinoma. P16 is a reliable, sensitive surrogate marker for HPV and confers a positive prognostic advantage. Basaloid differentiation on hematoxylin and eosin (H&E) staining is anecdotally noted by some pathologists to be associated with p16 positivity. This association, however, has not been adequately quantified in the literature, nor has the prognostic implications of basaloid differentiation been described. 1) To correlate the H&E staining feature of basaloid differentiation with p16 positivity in oropharyngeal cancer. 2) To investigate the prognostic utility of basaloid differentiation in oropharyngeal cancer survival. Retrospective cross-sectional study of all patients diagnosed with and treated for oropharyngeal cancer at a single tertiary cancer center from 2002 to 2009. Tissue microarrays (TMAs) were generated from 208 oropharyngeal tumor specimens stained with H&E and immunohistochemical markers. These oropharyngeal TMAs were utilized in several previous publications. Samples were scored for basaloid differentiation by a pathologist blinded to the p16 result. A multivariate survival analysis with Cox-r...Continue Reading

References

Dec 1, 1982·American Journal of Clinical Oncology·M M OkenP P Carbone
May 4, 2000·Journal of the National Cancer Institute·M L GillisonD Sidransky
Mar 1, 2006·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Samir K El-Mofty, Sushama Patil
Feb 10, 2009·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Anthony C NicholsJames W Rocco
Jul 1, 2010·The American Journal of Surgical Pathology·James S LewisSamir K El-Mofty
Aug 31, 2010·The Laryngoscope·Abie H MendelsohnMaie A St John
Sep 29, 2011·European Annals of Otorhinolaryngology, Head and Neck Diseases·X DufourJ Lacau St Guily
Oct 5, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Andrew G SchacheRichard J Shaw
Aug 14, 2012·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A M HongB Rose
Aug 16, 2012·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Alexander C KlimowiczJoseph C Dort

❮ Previous
Next ❯

Citations

Sep 17, 2015·Journal of Otolaryngology - Head & Neck Surgery = Le Journal D'oto-rhino-laryngologie Et De Chirurgie Cervico-faciale·Jessica ClarkVincent L Biron
Mar 7, 2014·International Forum of Allergy & Rhinology·Vincent L BironArnaud F Bewley
Mar 19, 2015·Head & Neck·Hadi SeikalyJeffrey R Harris
Apr 19, 2015·Journal of Otolaryngology - Head & Neck Surgery = Le Journal D'oto-rhino-laryngologie Et De Chirurgie Cervico-faciale·Timothy CooperHadi Seikaly
Oct 30, 2016·Journal of Otolaryngology - Head & Neck Surgery = Le Journal D'oto-rhino-laryngologie Et De Chirurgie Cervico-faciale·Sherif IdrisVincent L Biron
Feb 2, 2017·Journal of Otolaryngology - Head & Neck Surgery = Le Journal D'oto-rhino-laryngologie Et De Chirurgie Cervico-faciale·Cameron LindsayVincent L Biron
Dec 19, 2017·Archives of Pathology & Laboratory Medicine·James S LewisWilliam C Faquin
Sep 21, 2018·Journal of Otolaryngology - Head & Neck Surgery = Le Journal D'oto-rhino-laryngologie Et De Chirurgie Cervico-faciale·Hani Z MarzoukiHadi Seikaly
Jan 8, 2019·Cancer Biomarkers : Section a of Disease Markers·Hedyeh ZiaiVincent L Biron
Jan 12, 2019·Journal of Otolaryngology - Head & Neck Surgery = Le Journal D'oto-rhino-laryngologie Et De Chirurgie Cervico-faciale·Shanmugappiriya SivarajahVincent L Biron
Nov 26, 2015·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Eddy Wh LamPaul Ks Chan

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsy
biopsies
PCR

Software Mentioned

SPSS
Excel

Related Concepts

Related Feeds

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.