Prognostic Utility of FBLN2 Expression in Patients With Urothelial Carcinoma

Frontiers in Oncology
Wei-Ming LiChien-Feng Li

Abstract

Background: Abnormal extracellular matrix (ECM) remodeling plays an essential role in urothelial carcinoma (UC) invasiveness and metastasis. Focusing on the ECM structural constituent (GO: 0005201), we recognized a significant upregulation of the fibulin 2 gene (FBLN2) during UC progression in a published UC transcriptome (GSE31684). Thus, we aimed to investigate the roles of FBLN2 expression and its prognostic value in upper urinary tract UC (UTUC) and urinary bladder UC (UBUC) in our large, well-characterized cohort. Patients and Methods: Clinicopathological data and formalin-fixed paraffin-embedded UC tissues were analyzed retrospectively. We determined FBLN2 expression using immunohistochemical staining assessed by H-scores. FBLN2 expression correlated with clinicopathological features and patient outcomes, including metastasis-free survival (MFS) and disease-specific survival (DSS). Statistical analyses were performed using Pearson's chi-square test, Kaplan-Meier estimates of DSS and MFS, and the Cox proportional hazards model. We used Ingenuity Pathway Analysis (IPA) to clarify the functional significance of dysregulated FBLN2 in UC. Results: Data from 295 UBUC and 340 UTUC patients were available for the final evaluation...Continue Reading

References

Jun 5, 2003·Nature Reviews. Molecular Cell Biology·Rupert TimplMon-Li Chu
Dec 4, 2003·EMBO Reports·W Scott ArgravesWilliam M Gallagher
Jun 3, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Ekaterini BlaveriFrederic M Waldman
Jan 25, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Marta Sanchez-CarbayoCarlos Cordon-Cardo
Apr 26, 2007·The American Journal of Pathology·Chun-Hui YiMichael A Hollingsworth
Feb 4, 2009·Cellular and Molecular Life Sciences : CMLS·S de VegaY Yamada
Mar 8, 2011·Cell·Douglas Hanahan, Robert A Weinberg
Dec 14, 2011·Nature Reviews. Urology·George J Netto
Feb 22, 2012·The Journal of Cell Biology·Pengfei LuZena Werb
May 15, 2012·Seminars in Cell & Developmental Biology·Cassandra L BuchheitZachary T Schafer
Jul 12, 2012·Cancer Letters·Alvaro J ObayaSantiago Cal
Jun 21, 2013·PloS One·Brandi N BairdJonathan M Kurie
Aug 8, 2014·Nature Reviews. Cancer·Cassandra L BuchheitZachary T Schafer
Nov 22, 2014·Nature Reviews. Molecular Cell Biology·Caroline BonnansZena Werb
Dec 10, 2014·Journal of Surgical Oncology·Hsiang-Ying LeeWen-Jeng Wu
Jul 5, 2016·European Urology·J Alfred WitjesMaria J Ribal
May 19, 2018·Urologic Oncology·Benjamin L WoolbrightJohn A Taylor
Jan 9, 2020·CA: a Cancer Journal for Clinicians·Rebecca L SiegelAhmedin Jemal

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