Prognostic Utility of Indoxyl Sulfate for Patients with Acute Coronary Syndrome

Journal of Atherosclerosis and Thrombosis
Ippei WatanabeToshisuke Morita

Abstract

We investigated whether indoxyl sulfate (IS), a protein-bound uremic toxin, predicts prognosis after acute coronary syndrome (ACS). Serum IS level was determined prospectively in 98 patients who underwent successful primary percutaneous coronary intervention for ACS. Patients on hemodialysis were excluded. The endpoint of this study was six-month composite events including death, nonfatal myocardial infarction, heart failure requiring hospitalization, and adverse bleeding events. During the mean follow-up period of 168 days, composite events occurred in 13.3% of cases. Serum IS level was significantly higher in subjects who developed composite events than in those without events (0.14±0.11 mg/dl vs. 0.06±0.04 mg/dl; p<0.001). After adjusting for confounding factors, a Cox proportional hazard analysis revealed that the IS level (hazard ratio (HR): 10.6; 95% confidence interval (CI): 1.63-69.3, p=0.01), hemoglobin level (HR: 0.61; 95% CI: 0.43-0.87; p<0.01), and left ventricular ejection fraction (LVEF) (HR: 0.95; 95% CI: 0.91-0.99; p=0.03) were independent predictive factors of composite events. Furthermore, IS level significantly conferred additional value to the combined established risks of LVEF and hemoglobin level for predi...Continue Reading

References

Oct 29, 2003·Archives of Internal Medicine·Christopher B GrangerUNKNOWN Global Registry of Acute Coronary Events Investigators
Oct 29, 2003·Circulation·Mark J SarnakUNKNOWN American Heart Association Councils on Kidney in Cardiovascular Disease, High Blood Pressure Research, Clinical Cardiology,
Jul 29, 2008·Archives of Cardiovascular Diseases·Sylvestre MaréchauxPierre Vladimir Ennezat
Feb 14, 2009·Journal of the American College of Cardiology·Mariell Jessup, Maria Rosa Costanzo
Apr 15, 2010·American Journal of Nephrology·Zohra TumurToshimitsu Niwa
May 15, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Cheng-Jui LinHan-Hsiang Chen
Jun 16, 2010·Circulation·Jeremy S Bock, Stephen S Gottlieb
Sep 30, 2010·Clinical Journal of the American Society of Nephrology : CJASN·Mina YuDuk-Hee Kang
Oct 13, 2010·The Journal of Biological Chemistry·Shunsuke ItoMasayuki Yoshida
Aug 28, 2012·European Heart Journal·UNKNOWN Task Force on the management of ST-segment elevation acute myocardial infarction of the European Society of Cardiology (ESC)Doron Zahger
Oct 6, 2012·Circulation Journal : Official Journal of the Japanese Circulation Society·Ippei WatanabeToshisuke Morita
Oct 27, 2012·Circulation Journal : Official Journal of the Japanese Circulation Society·Shuzo ShimazuToyoaki Murohara
Feb 5, 2013·Clinical and Investigative Medicine. Médecine Clinique Et Experimentale·Chia-Chang HsuI-Ting Tsai
Sep 7, 2013·Journal of the American Society of Nephrology : JASN·Anneleen PletinckRaymond Vanholder
Apr 15, 2014·Journal of Atherosclerosis and Thrombosis·Masayuki KoizumiToshisuke Morita
Jan 6, 2015·Journal of Renal Nutrition : the Official Journal of the Council on Renal Nutrition of the National Kidney Foundation·Suree Lekawanvijit, Henry Krum
Apr 22, 2015·Physiological Reports·Indrajeetsinh RanaFadi J Charchar
May 15, 2015·Circulation Journal : Official Journal of the Japanese Circulation Society·Hiromu YamazakiMasataka Sata
Jan 12, 2016·British Journal of Pharmacology·Hideki FujiiShinichi Nishi
Feb 11, 2016·Journal of Atherosclerosis and Thrombosis·Shunsuke ItoMasayuki Yoshida
Feb 18, 2016·Kidney International·Szu-Chun HungDer-Cherng Tarng
Feb 9, 2017·Journal of the American Heart Association·Szu-Chun HungDer-Cherng Tarng

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Citations

Jun 21, 2019·Journal of Atherosclerosis and Thrombosis·Toshiaki Nakano
Aug 23, 2019·Journal of Atherosclerosis and Thrombosis·Hiroto HiyamutaTakanari Kitazono
Apr 18, 2020·American Journal of Hypertension·Takayuki MatsumotoTsuneo Kobayashi
Jun 13, 2019·Clinical Chemistry and Laboratory Medicine : CCLM·Yuki FushimiToshisuke Morita

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Methods Mentioned

BETA
blood drawn

Software Mentioned

Statistical Package for R ( R Development Core

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