Abstract
We analysed the outcomes of 62 patients with refractory/relapsed diffuse large B-cell lymphoma (rrDLBCL) who had pre-transplantation fluorodeoxyglucose positron emission tomography/computed tomography (PET/CT) after R-DHAC (rituximab, dexamethasone, high-dose cytarabine, carboplatin) salvage chemotherapy, and were evaluated using Deauville criteria and total lesion glycolysis (TLG). A positive pre-transplantation PET/CT with Deauville score of 5 was associated with shorter progression-free survival (PFS) (P = 0·01), while a Deauville score of 4 was not predictive of outcome. Only pre-transplant TLG was significantly associated with both PFS (P = 0·005) and overall survival (P = 0·03). TLG deserves to be further investigated in prospective studies.
References
Dec 7, 1995·The New England Journal of Medicine·T PhilipJ L Harousseau
Oct 4, 2008·Cancer·Enrico DerenziniPier Luigi Zinzani
May 29, 2010·British Journal of Haematology·Michael DickinsonDavid Ritchie
Jul 28, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Christian GisselbrechtNorbert Schmitz
Jan 3, 2013·British Journal of Haematology·Philippe ArmandYi-Bin Chen
Feb 21, 2013·American Journal of Hematology·Irit AviviRachel Bar-Shalom
Aug 13, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Bruce D ChesonT Andrew Lister
Aug 13, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Sally F BarringtonBruce D Cheson
Mar 12, 2015·Blood·Craig S SauterCraig H Moskowitz
Mar 5, 2016·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Anne-Ségolène CottereauStéphanie Becker
Mar 11, 2016·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Pouya ZiaiOleg M Teytelboym
Feb 2, 2017·Haematologica·Mark HertzbergUNKNOWN Australasian Leukaemia Lymphoma Group (ALLG)
Apr 5, 2017·Annals of Hematology·B TessoulinSteven Le Gouill
Aug 31, 2017·Leukemia & Lymphoma·Allison WinterBrian T Hill
Jan 10, 2019·PloS One·Baoping GuoHong Cen