Abstract
Pancreatic neuroendocrine tumors (pNETs) are diverse diseases with different prognosis. The American Joint Committee on Cancer (AJCC) and the European Neuroendocrine Tumor Society (ENETS) introduced 2 different tumor node metastasis (TNM) stages, and the World Health Organization (WHO) proposed WHO 2010 grading system for pNETs. Therefore, we aimed to validate the prognostic relevance of these 3 systems for pNETs in South Korea. The Korean Society of Gastrointestinal Cancer created a retrospective registry of pNETs in 153 patients from 15 hospitals between 2002 and 2012. On the basis of the WHO 2010 grade, 2-year progression-free-survival (PFS) rates for G1, G2, and G3 were 92%, 62%, and 25% (P < 0.01). According to ENETS and AJCC staging, 2-year PFS rates for stages I through IV were 94%, 87%, 49%, 20%, and 92%, 61%, 60%, 20%, respectively (P < 0.01). A Cox multivariate regression analysis revealed that the only statistically significant prognostic factor was the TNM classification of either the AJCC or the ENETS stage (P < 0.01). In addition, the κ value between the AJCC and the ENETS stages was 0.46 indicating a "moderate" agreement (P < 0.01). The AJCC and ENETS TNM classifications for pNETs are prognostic for PFS and can b...Continue Reading
References
Oct 12, 2001·Cancer·K Hemminki, X Li
Jul 21, 2005·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Megan Dann FesinmeyerDeborah J Bowen
Mar 27, 2007·Gastroenterology·Côme LepageMichel Philippe Coleman
Apr 18, 2007·Archives of Surgery·Parsia A VagefiCarlos Fernández-Del Castillo
Sep 27, 2007·Annals of Surgical Oncology·James C YaoDouglas B Evans
Feb 29, 2008·The British Journal of Surgery·L FischerM W Büchler
Jun 21, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·James C YaoDouglas B Evans
Oct 15, 2008·Cancer·Oyvind HausoIrvin M Modlin
Jul 29, 2010·Pancreas·David S KlimstraSaul Suster
Jul 29, 2010·Pancreas·Aaron I VinikUNKNOWN North American Neuroendocrine Tumor Society (NANETS)
Jul 29, 2010·Pancreas·Matthew H KulkeUNKNOWN North American Neuroendocrine Tumor Society (NANETS)
Feb 11, 2011·The New England Journal of Medicine·Eric RaymondPhilippe Ruszniewski
Feb 11, 2011·The New England Journal of Medicine·James C YaoUNKNOWN RAD001 in Advanced Neuroendocrine Tumors, Third Trial (RADIANT-3) Study Group
Jun 29, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jonathan R StrosbergLarry K Kvols
Mar 15, 2012·Annals of Surgery·Jonathan R StrosbergLarry K Kvols
Apr 25, 2012·Journal of the National Cancer Institute·G RindiB Wiedenmann
Aug 8, 2012·Yonsei Medical Journal·Tak Geun OhSi Young Song
Oct 24, 2012·Cancer Research and Treatment : Official Journal of Korean Cancer Association·Mee-Yon ChoSei Jin Chang
Jul 10, 2013·Korean Journal of Pathology·Mee-Yon ChoEun Hee Choi
Jan 10, 2014·Cancer Medicine·Emilie MorinShereen Ezzat
Jun 20, 2014·Pancreas·Min YangLi Wang
Citations
Jan 24, 2017·Surgery·Roxanne TeoSimon Ong
Nov 1, 2017·Abdominal Radiology·Prasad R ShankarRavi K Kaza
Sep 9, 2017·Cancer Chemotherapy and Pharmacology·Kyong Joo LeeWoo Jin Lee
Jun 24, 2017·World Journal of Clinical Oncology·Mitsuru SugimotoHiromasa Ohira
Dec 1, 2017·Annals of Surgery·Luca LandoniClaudio Bassi
Nov 19, 2019·Expert Review of Anticancer Therapy·Lingaku LeeRobert T Jensen
Nov 29, 2017·Oncotarget·Peng LiuPeng Gong
Feb 6, 2018·Experimental and Therapeutic Medicine·Di XiaYubao Zhang
May 10, 2018·Scientific Reports·Yong GaoYi Miao
Oct 1, 2017·Experimental and Therapeutic Medicine·Qinghui NiuGuanglan Wang
Apr 25, 2019·The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi·Chang Min Cho
May 16, 2019·Pancreas·Min YangXu-Bao Liu
Sep 24, 2020·BMC Cancer·Min YangYi Zhang
May 11, 2017·World Journal of Gastroenterology : WJG·Yang LiGuo-Feng Qu
Feb 6, 2020·Medicine·Ben-Yuan DengYi Zhang
Sep 3, 2020·Medicine·Hua LiuJian Fei
May 11, 2020·Clinics and Research in Hepatology and Gastroenterology·Yaoyao SunQiong Yu
Apr 2, 2021·Curēus·Samyak DhruvDeeb Liliane
Oct 4, 2018·Neuroendocrinology·Robert T JensenUNKNOWN ENETS 2016 Munich Advisory Board Participants
Nov 13, 2021·Experimental and Therapeutic Medicine·Oana Alexandra CiobanuSimona Fica