Prognostic Value and Immune Infiltrates of ABCA8 and FABP4 in Stomach Adenocarcinoma.

BioMed Research International
Ya GuoYa Li Wang

Abstract

Stomach adenocarcinoma (STAD) is a common malignancy worldwide with poor prognosis. Therefore, it is important to identify a valuable prognostic biomarker for STAD. The aim of present study was to identify novel prognostic biomarkers for STAD and evaluate the potential role of hub genes in STAD. Gene Expression Profiling Interactive Analysis (GEPIA) and Cancer RNA-Seq Nexus were performed to identify differentially expressed genes (DEGs). Subsequently, hub genes were selected by a Venn diagram, and the expression of key genes was confirmed by UALCAN database. Furthermore, survival analysis of these hub genes was performed using Oncolnc and Human Protein Atlas (HPA) database. Gene alteration status of hub genes was assessed by cBioPortal. Finally, we investigated the association between hub genes and immune cell infiltration in STAD through the Tumor Immune Estimation Resource (TIMER) and GEPIA database. Three common hub genes were obtained, including 2 downregulated DEGs (ABCA8 and FABP4) and one upregulated DEG (SLC52A3). Furthermore, increased expression of ABCA8 and FABP4 and decreased expression of SLC52A3 were correlated with poor prognosis. Meanwhile, three hub genes showed genetic alterations in various datasets of STAD....Continue Reading

References

May 18, 2001·Nature·L A Liotta, E C Kohn
Feb 8, 2008·BMC Genomics·Hui YeXiaofeng Zhou
Jun 25, 2014·Journal of the National Cancer Institute·Ellen L HedditchMichelle J Henderson
Aug 16, 2014·Cancers·Theerawut ChanmeeNaoki Itano
Oct 30, 2014·Expert Opinion on Therapeutic Targets·Belal Chaudhary, Eyad Elkord
Apr 22, 2015·International Journal of Oncology·Xia LiuFuqiang Yin
Oct 16, 2015·BMC Cancer·Rita DemidenkoSonata Jarmalaite
Dec 15, 2015·Applied Immunohistochemistry & Molecular Morphology : AIMM·Yuan LuoYuan Yuan
Sep 15, 2016·Technology in Cancer Research & Treatment·Xin ZhouBing-Dong Zhu
Sep 21, 2016·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Ying ChenJohn A Martignetti
May 5, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Pavel DvorakPavel Soucek
Jul 22, 2017·Neoplasia : an International Journal for Oncology Research·Darshan S ChandrashekarSooryanarayana Varambally
Feb 13, 2018·Cellular and Molecular Life Sciences : CMLS·Lin LongLi-Yan Xu
May 21, 2020·Journal of Experimental & Clinical Cancer Research : CR·Yifeng CuiLianxin Liu

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Methods Mentioned

BETA
RNA-Seq

Software Mentioned

CRN
TIMER
GEPIA

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.