Prognostic value and interobserver agreement of endoscopic ultrasonography for superficial squamous cell carcinoma of the esophagus: a prospective study

International Journal of Gastrointestinal Cancer
Hideo YanaiToyokazu Kawano

Abstract

Submucosal invasion of superficial esophageal cancer (SEC) is related to the prognosis. We prospectively analyzed outcomes of SEC in patients staged by endoscopic ultrasonography (EUS). We staged 31 endoscopically diagnosed SEC cases using a 20/15-MHz thin probe. The EUS tumor stage was classified as EUSM (limited within mucosa), EUS-SM (with submucosal invasion), or EUS-MP over (invading the muscularis propria or deeper). Lymph node metastasis and 2-yr survival were analyzed according to the EUS tumor stage in 29 squamous cell carcinoma cases. Interobserver agreement of the EUS stage was tested between the examiner and a blind reviewer. Lymph node metastasis was significantly frequent in the EUS-SM group (8 of 18 cases [44.4%]) compared with the EUS-M group (1 of 10 cases [10%]) (p = 0.03). Patient survival at 2 yr after initial therapy was 72.2% in the EUS-SM group and 90% in the EUS-M group. Death from cancer was noted only in the EUS-SM group (three cases). The accuracy rates of EUS tumor staging were 74.1% by the examiner and 66.7% by the blind reviewer, with moderate interobserver agreement (kappa = 0.46). Thin-probe EUS can classify SEC into two groups: the EUS-M group with excellent outcome and the EUS-SM group with a s...Continue Reading

Citations

Apr 17, 2008·Cancer Metastasis Reviews·Aaron P BrownKevin A Camphausen
Mar 15, 2012·Journal of Gastroenterology and Hepatology·Pietro FusaroliGiancarlo Caletti
May 31, 2018·European Journal of Gastroenterology & Hepatology·Ihab I El HajjMohammad Al-Haddad
Feb 9, 2006·The American Journal of Gastroenterology·Massimo ConioRosangela Filiberti
Jul 26, 2008·Scandinavian Journal of Gastroenterology·Evangelos Kalaitzakis, John Meenan
Apr 5, 2014·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·J LuM Jin
Nov 19, 2020·Diagnostics·Akira YamamiyaKenichi Goda

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