PMID: 26320427Sep 1, 2015Paper

Prognostic Value of β-catenin Expression in Breast Cancer Patients: a Meta-analysis

Asian Pacific Journal of Cancer Prevention : APJCP
Depu ZhangJing-He Lang

Abstract

β-catenin plays a crucial role in the progression of breast cancer (BC) and a prognostic role of in BC patients has been widely reported. However, controversy still remains. Identical search strategies were used to search relevant literature in electronic databases updated to July 1, 2014. Individual hazard ratios (HRs) and 95% confidence intervals (CIs) were extracted and pooled HRs with 95%CIs were used to evaluate the strength of association between positive β-catenin expression in different subcellular locations and survival results of BC patients. Subgroup and meta-regression analyses were performed to explore heterogeneity. Funnel plots of Begg's and Egger's linear regression test were used to investigate publication bias. Heterogeneity and sensitivity were also assessed. All the work was completed using STATA. A total of 2,204 patients from 12 evaluative studies were finally included. Pooled HRs and 95%CIs suggested that β-catenin expression in cytoplasm/nucleus had an unfavorable impact on both overall survival (OS) (HR: 1.93, 95%CI: 1.40-2.65) and disease free survival (DFS)/ recurrent free survival (RFS) (HR: 1.60, 95%CI: 1.20-2.13) in BC patients. However, here was no significant association between β-catenin express...Continue Reading

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Citations

Apr 25, 2020·Frontiers in Oncology·Xiaoliang XieTianyou Fan
Oct 27, 2016·American Journal of Clinical Pathology·Tiansheng ShenShi Wei
Apr 13, 2021·Biochimica Et Biophysica Acta. Molecular Basis of Disease·Ragini YeeravalliAmitava Das

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