Prognostic value of 1H-MRS in neonatal encephalopathy

Pediatric Neurology
Luis Fernando Garcias da SilvaM L Nunes

Abstract

The aim of this study was to determine the prognostic value of proton magnetic resonance spectroscopy in neonatal encephalopathy. Studies were carried out in 11 consecutive term newborns with encephalopathy probably caused by hypoxic-ischemic injury. The clinical evaluation included pregnancy data, labor conditions, encephalopathy grade, presence of seizures, and necessity of antiepileptic drug therapy. Polygraphic recordings were obtained in all cases. Interest areas evaluated by spectroscopy were the basal ganglia and thalami. Among the cases, N-acetylaspartate/creatine, choline/creatine, and lactate/creatine ratios were calculated and related to the clinical variables, polygraphic recordings, and 6-month neurodevelopmental outcome. Abnormal follow-up occurred in 5 of 11 patients (45.4%) and was clearly related to an Apgar score <5 at 5 minutes (P = 0.003), encephalopathy grade (P = 0.02), early neonatal seizures (P = 0.02), and antiepileptic therapy (P = 0.01). No relationship was observed between spectroscopy results and polygraphic recordings profile. The lowest mean N-acetylaspartate/creatine ratio was observed in four of five patients with an adverse outcome and, although not statistically significant, demonstrated a cle...Continue Reading

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Citations

Apr 16, 2014·Pediatric Neurology·Erin E SpiesMargaret C McBride
Aug 10, 2013·Neuroimaging Clinics of North America·Paul A CarusoEva-Maria Ratai
Nov 9, 2011·Journal of Korean Medical Science·Hyun-Kyung ParkKi-Soo Kim
Jul 14, 2010·Sleep Medicine·Magda Lahorgue Nunes, Jaderson Costa da Costa

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