Abstract
The aim of this study was to determine the prognostic value of proton magnetic resonance spectroscopy in neonatal encephalopathy. Studies were carried out in 11 consecutive term newborns with encephalopathy probably caused by hypoxic-ischemic injury. The clinical evaluation included pregnancy data, labor conditions, encephalopathy grade, presence of seizures, and necessity of antiepileptic drug therapy. Polygraphic recordings were obtained in all cases. Interest areas evaluated by spectroscopy were the basal ganglia and thalami. Among the cases, N-acetylaspartate/creatine, choline/creatine, and lactate/creatine ratios were calculated and related to the clinical variables, polygraphic recordings, and 6-month neurodevelopmental outcome. Abnormal follow-up occurred in 5 of 11 patients (45.4%) and was clearly related to an Apgar score <5 at 5 minutes (P = 0.003), encephalopathy grade (P = 0.02), early neonatal seizures (P = 0.02), and antiepileptic therapy (P = 0.01). No relationship was observed between spectroscopy results and polygraphic recordings profile. The lowest mean N-acetylaspartate/creatine ratio was observed in four of five patients with an adverse outcome and, although not statistically significant, demonstrated a cle...Continue Reading
References
Nov 1, 1991·American Journal of Diseases of Children·K B Nelson, A Leviton
Feb 1, 1991·American Journal of Obstetrics and Gynecology·C L WinklerC G Brumfield
Mar 1, 1990·The New England Journal of Medicine·K K ShyM A Stenchever
May 1, 1989·American Journal of Diseases of Children·J M PerlmanE Amon
Sep 1, 1989·American Journal of Obstetrics and Gynecology·L C GilstrapB B Little
Jan 1, 1987·Annals of the New York Academy of Sciences·P A Bottomley
Oct 1, 1987·American Journal of Obstetrics and Gynecology·D I HollanderT Koch
Nov 1, 1986·The Journal of Pediatrics·E A CatlinW Oh
May 1, 1985·Early Human Development·M L LeveneT H Williams
Jan 1, 1981·The Journal of Pediatrics·N N FinerK L Peters
Jul 1, 1996·AJR. American Journal of Roentgenology·Z WangR Sauter
Jul 1, 1996·Pediatric Research·J PenriceE O Reynolds
Apr 1, 1996·Pediatric Research·J D HanrahanA D Edwards
Jul 17, 1998·Pediatric Research·E NovotnyM Shevell
Sep 4, 1998·Pediatric Research·J D HanrahanD Azzopardi
Feb 17, 2000·Journal of Magnetic Resonance Imaging : JMRI·B A HolshouserD B Hinshaw
Aug 30, 2000·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·A J OliveiraJ C da Costa
Sep 21, 2000·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·A J OliveiraJ C da Costa
Feb 28, 2002·Neurology·S P MillerA J Barkovich
Dec 4, 2002·Radiology·Maria K ZarifiA Aria Tzika
Jul 25, 2003·Pediatric Neurology·Seth A KaufmanJ Colin Partridge
Apr 17, 2004·Pediatric Neurology·Luis Fernando Garcias Da SilvaJaderson Costa Da Costa
Apr 23, 2004·Archives of Disease in Childhood. Fetal and Neonatal Edition·N J Robertson, J S Wyatt
Apr 15, 2005·Arquivos de neuro-psiquiatria·Magda Lahorgue NunesJaderson Costa da Costa
Citations
Apr 16, 2014·Pediatric Neurology·Erin E SpiesMargaret C McBride
Apr 12, 2015·Pediatrics and Neonatology·Tania NanavatiPaola Pergami
Aug 10, 2013·Neuroimaging Clinics of North America·Paul A CarusoEva-Maria Ratai
Jan 12, 2010·Brain & Development·Gina AncoraGiacomo Faldella
Nov 9, 2011·Journal of Korean Medical Science·Hyun-Kyung ParkKi-Soo Kim
Mar 29, 2019·Pediatric Radiology·Ashley M LuckeMagdalena Sanz Cortes
Jul 14, 2010·Sleep Medicine·Magda Lahorgue Nunes, Jaderson Costa da Costa