Prognostic value of 68 Ga PSMA I&T PET/CT SUV parameters on survival outcome in advanced prostat cancer.

Annals of Nuclear Medicine
Halil KömekSerdar Altindag

Abstract

To determine the association of 68 Ga-PSMA-I&T PET/CT SUV parameters with survival outcome in advanced prostate cancer patients. A total of 148 consecutive patients mean age: 69.3 ± 7.8 years with advanced prostate cancer who underwent 68 Ga-PSMA-I&T PET/CT were included in this retrospective study. Data on previous treatments, serum PSA levels (ng/mL), 68 Ga-PSMA-I&T PET/CT findings metastases as well as survival data were recorded. Multivariate regression analysis revealed that Level 1 LN SUV/Liver SUV ratios > 2.17 (OR 4.262; 95% CI 1.104-16.453, p = 0.035), bone SUV > 10.7(OR 23.650; 95% CI 4.056-137.888, p < 0.001), bone SUV/spleen SUV ratio > 1.842 (OR 25.324; 95% CI 4.204-152.552, p < 0.001), highest SUVmax/liver SUV ratio > 2.32 (OR 19.309; 95% CI 1.730-209.552, p = 0.016) and highest SUVmax/spleen SUV ratio > 1.842 (OR 22.354; 95% CI 2.637-189.493, p = 0.004) were significant in the determination of increased mortality risk in advanced prostate cancer patients. Our findings, for the first time in literature, provided evidence on potential utility of tracer uptake (SUV) cut-off values on 68 Ga-PSMA PET/CT in identification of the survival outcome of patients with metastatic disease and thereby in assisting in the select...Continue Reading

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Citations

Nov 24, 2019·Annals of Nuclear Medicine·Seigo Kinuya
Nov 7, 2019·European Journal of Nuclear Medicine and Molecular Imaging·Martina SolliniMargarita Kirienko
Mar 5, 2019·Nuclear Medicine and Molecular Imaging·Seigo Kinuya
Oct 5, 2019·Current Opinion in Urology·Adnan AliNoel W Clarke
Mar 9, 2021·Frontiers in Oncology·Panagiotis J VlachostergiosScott T Tagawa
Feb 10, 2021·Nuclear Medicine Communications·Ayşegül AksuGamze Çapa Kaya

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