Prognostic Value of a Long Non-coding RNA Signature in Localized Clear Cell Renal Cell Carcinoma

European Urology
Le QuLin-Hui Wang

Abstract

Long non-coding RNAs (lncRNAs) can be used as prognostic biomarkers in many types of cancer. We sought to establish an lncRNA signature to improve postoperative risk stratification for patients with localized clear cell renal cell carcinoma (ccRCC). Based on the RNA-seq data of 444 stage I-III ccRCC tumours from The Cancer Genome Atlas project, we built a four-lncRNA-based classifier using the least absolute shrinkage and selection operation (LASSO) Cox regression model in 222 randomly selected samples (training set) and validated the classifier in the remaining 222 samples (internal validation set). We confirmed this classifier in an external validation set of 88 patients with stage I-III ccRCC from a Japan cohort and using quantitative reverse transcription polymerase chain reaction (RT-PCR) in another three independent sets that included 1869 patients from China with stage I-III ccRCC. Univariable and multivariable Cox regression, Harrell's concordance index (c-index), and time-dependent receiver operating characteristic curves were used to evaluate the association of the classifier with overall survival, disease-specific survival, and disease-free survival. Using the LASSO Cox regression model, we built a classifier named R...Continue Reading

Citations

May 6, 2019·Current Treatment Options in Oncology·Nieves Martinez ChanzaLauren C Harshman
May 21, 2019·The International Journal of Biological Markers·Yunfang HuangFang Xu
Sep 24, 2019·Journal of Cellular Biochemistry·Yiping ZhuXiaoping Qian
May 22, 2019·Nature Reviews. Urology·Ronan FlippotGabriel G Malouf
Dec 10, 2020·Cancer Cell International·Yejinpeng WangGang Wang
Apr 3, 2021·Journal of Cellular and Molecular Medicine·Wen-Jie LuoYi-Ping Zhu

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