Prognostic value of a three-grade classification in primary epithelial parotid carcinoma: result of a histological review from a 20-year experience of total parotidectomy with neck dissection in a single institution

European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)
Elham JouzdaniRenaud Garrel

Abstract

The tumour grading of primary parotid cancers (PPCs) remains controversial. A 20-year standardised single centre treatment has been assessed retrospectively. The histological review of 155 consecutively treated parotid malignancies identified 96 suitable cases for univariate and multivariate survival analyses. Treatment involved total parotidectomy, neck dissection and post-operative radiotherapy in, respectively, 91.7%, 83.3% and 70.4% of cases. The 5-year overall survival, disease-specific and recurrence-free survival rates were 79.4%, 83.5% and 70.8%, respectively. Univariate analysis confirmed the classical prognostic factors, i.e. age>60 years, male gender, facial palsy, hardness of the tumour, clinical stage, tumour grade, facial nerve invasion and lymph node metastases. Multivariate analysis identified a three-grade classification just after the clinical stage as the most important prognostic factor. This study identifies the prognostic significance of intermediate grade tumours.

References

Mar 1, 1991·Archives of Otolaryngology--head & Neck Surgery·W J KaneJ E Lewis
Jul 13, 2002·Journal of Surgical Oncology·Frederick L Greene, Leslie H Sobin
Aug 5, 2003·The Laryngoscope·Christian GodballeJørgen Johansen
Sep 7, 2005·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·John P LeonettiBrian Herr
Sep 9, 2005·The Laryngoscope·Brian A MooreGary L Clayman
Mar 25, 2008·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·J P KlussmannO Guntinas-Lichius

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Citations

Aug 19, 2011·Der Pathologe·S Schwarz-Furlan
Jul 31, 2012·Oral and Maxillofacial Surgery·Tobias EttlTorsten E Reichert
Apr 2, 2013·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·Giuseppe MercanteGiuseppe Spriano
Dec 15, 2015·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Tobias AchTobias Ettl
Feb 28, 2014·Cancer Medicine·Yukio WatabeKazufumi Honda
Jun 20, 2013·Head & Neck·Tobias EttlHeinrich Iro
Sep 10, 2014·Head & Neck·Asta ScesnaiteRegine Schneider-Stock
Dec 21, 2010·Archives of Oral Biology·Juliana Mandato FerragutEduardo José Caldeira
Jul 30, 2016·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Lorenz KadletzClaudia Lill
Sep 13, 2019·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Bo-Wen LeiQing-Hai Ji
Jan 17, 2020·Acta Oto-laryngologica·Masaaki HigashinoYoshinobu Hirose
Dec 4, 2014·Molecular and Clinical Oncology·Hideo ShigeishiMasaaki Takechi
Jun 7, 2019·The Journal of Laryngology and Otology·T NakanoT Nakagawa
Nov 23, 2020·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Daniele BorsettoPasquale Di Maio
Sep 10, 2021·The Annals of Otology, Rhinology, and Laryngology·Médarine RochPatrice Gallet

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