PMID: 6981385Aug 1, 1982Paper

Prognostic value of anti-dsDNA in SLE

Annals of the Rheumatic Diseases
A J SwaakE W Feltkamp

Abstract

In a prospective longitudinal study 130 patients with systemic lupus erythematosus (SLE) were studied at least monthly for a relationship between the anti-dsDNA levels and disease activity. We observed 13 patients who developed 15 periods of exacerbations of their disease. All 15 exacerbations were preceded by a continuous increase of the anti-dsDNA levels. In 13 of the 15 exacerbations studied the exacerbation was preceded by an increase of anti-dsDNA with a doubling time (T2) of less than 6 weeks; in 4 of the 5 other exacerbations the T2 was less than 10 weeks. Four other patients with an increase of the anti-dsDNA levels showed no exacerbation. In these 4 patients the T2 was larger than 10 weeks. The other 113 patients did not show an increase of anti-dsDNA over the 2 years of monitoring and showed no signs of serious disease activity (no major symptoms). These observations suggest that an SLE patient who is followed up frequently and who shows a continuous increase of anti-dsDNA witha T2 shorter than 10 weeks is bound to develop an exacerbation.

References

Jan 1, 1975·Scandinavian Journal of Rheumatology. Supplement·L A AardenT E Feltkamp
Mar 1, 1979·Arthritis and Rheumatism·A J SwaakT E Feltkamp
Sep 1, 1976·Arthritis and Rheumatism·R W Lightfoot, G R Hughes
Jan 1, 1976·Journal of Immunological Methods·L A AardenE R De Groot
Jan 1, 1976·Journal of Immunological Methods·L A ArdenT E Feltkamp
Jan 1, 1975·Scandinavian Journal of Rheumatology. Supplement·R W LightfootN Levesanos
Jan 1, 1974·Arthritis and Rheumatism·P Hasselbacher, E C LeRoy
Aug 1, 1974·The British Journal of Dermatology·P DavisG R Hughes
Jul 1, 1974·Annals of the Rheumatic Diseases·P G RochmisN J Zvaifler
Mar 7, 1968·The New England Journal of Medicine·P H Schur, J Sandson
Apr 1, 1968·Virology·R T Espejo, E S Canelo
Sep 25, 1969·The New England Journal of Medicine·T PincusN Talal

❮ Previous
Next ❯

Citations

Oct 17, 2002·Arthritis and Rheumatism·Arthur F KavanaughUNKNOWN American College of Rheumatology Ad Hoc Committee on Immunologic Testing Guidelines
Jan 1, 1983·Rheumatology International·T HelveO Wegelius
Jan 1, 1986·Rheumatology International·M Gripenberg, T Helve
Nov 1, 1992·Molecular Biology Reports·R Smeenk, M Hylkema
Jun 8, 2002·Toxicology Letters·David D'Cruz
Aug 15, 2006·Annals of the Rheumatic Diseases·G S AlarcónUNKNOWN LUMINA Study Group
Sep 1, 1989·Annals of the Rheumatic Diseases·J C NossentA J Swaak
Oct 1, 1990·Annals of the Rheumatic Diseases·R H DerksenR J Smeenk
Jul 27, 2000·Journal of Clinical Pathology·W Egner
Mar 1, 1990·Clinical Rheumatology·A van DamT Cuypers
Jan 1, 1991·Rheumatology International·R J SmeenkA J Swaak
Apr 22, 1988·Journal of Immunological Methods·R J SmeenkT J Swaak
Apr 1, 1989·Kidney International·J A Schifferli, R P Taylor
Feb 28, 2002·American Journal of Clinical Pathology·Renato TozzoliUNKNOWN Italian Society of Laboratory Medicine Study Group on the Diagnosis of Autoimmune Diseases
Sep 1, 1995·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·L A HebertJ B Peter
May 1, 1984·Clinical and Experimental Dermatology·N R Rowell
Mar 1, 1988·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·M K LoftagerV Andersen
Nov 29, 2011·Clinica Chimica Acta; International Journal of Clinical Chemistry·Cheuk-Chun SzetoPhilip Kam-Tao Li
Jan 1, 1983·The British Journal of Radiology·I Watt, P A Dieppe

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.